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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study
International Journal of Cancer, Volume 55, No. 2, Year 1993
Notification
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Description
Data from a hospital‐based case‐control study collected in 11 participating centers in 9 countries were analyzed to determine whether use of combined oral contraceptives alters risk of invasive squamous‐cell cervical cancer. Information on prior use of oral contraceptives, screening for cervical cancer, and suspected risk factors for this disease were ascertained from interviews of 2361 cases and 13,644 controls. A history of smoking and anal and genital warts was obtained, and blood specimens were collected for measurement of antibodies against herpes simplex and cytomegalo viruses, from selected sub‐sets of these women, as was a sexual history from interviews of husbands. The relative risk of invasive squamous‐cell cervical carcinoma was estimated to be 1.31, with a 95% confidence interval that excluded one, in women who ever used combined oral contraceptives. Risk of this disease increased significantly with duration of use after 4 to 5 years from first exposure, and declined with the passage of time after cessation of use to that of non‐users in about 8 years. No sources of bias or confounding were identified that offered plausible explanations for these findings. The strength of these results, and their consistency with those from other studies, suggest that a causal relationship may exist between use of combined oral contraceptives and squamous‐cell cervical carcinoma. Women who have used these products for 4 or more years, and who most recently used them within the past 8 years, should receive high priority for cervical cytologic screening. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Berry, Geoffrey
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
MacLennan, Robert A.
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Shearman, Rodney P.
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Jelihovsky, Tatiana
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Booth, Joan Cooper
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Molina, Ramiro Cartes
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Martínez, Luis
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Salas, Oriana
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Dabancens, Alfredo O.
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Zhiheng, Chen
Colombia, Cali
Hospital Universitario
Yun, Tao
Colombia, Cali
Hospital Universitario
Wei, Huyong
Colombia, Cali
Hospital Universitario
Cuadros, Alvaro
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Aristizabal, Nubia
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Modan, Baruch
Kenya, Nairobi
University of Nairobi
Ron, Elaíne
Kenya, Nairobi
University of Nairobi
Alfandary, Esther
Kenya, Nairobi
University of Nairobi
Mati, J. G.
Mexico, Mexico
Hospital General de Mexico
Kenya, Patrick R.
Mexico, Mexico
Hospital General de Mexico
Kungu, Alfred
Mexico, Mexico
Hospital General de Mexico
Gatei, David G.
Mexico, Mexico
Hospital General de Mexico
Cuevas, Hector Rodriguez
Nigeria, Ibadan
University College Hospital, Ibadan
Salazar, Socorro Benavides
Nigeria, Ibadan
University College Hospital, Ibadan
Palet, Antonio
Nigeria, Ibadan
University College Hospital, Ibadan
Ontiveros, Patricia
Nigeria, Ibadan
University College Hospital, Ibadan
Ibeziako, Patrick A.
Philippines, Manila
University of the Philippines Manila
Junaid, Tamaldeen A.
Philippines, Manila
University of the Philippines Manila
Aghediuno, P.
Philippines, Manila
University of the Philippines Manila
Abioye, A. A.
Philippines, Manila
University of the Philippines Manila
Apelo, Ruben A.
Thailand, Chaing Mai
Chiang Mai University
de la Cruz, Julietta R.
Thailand, Chaing Mai
Chiang Mai University
Baens, Jose
Thailand, Chaing Mai
Chiang Mai University
Canlas, Benjamin D.
Thailand, Chaing Mai
Chiang Mai University
Silpisornkosol, Suporn
Thailand, Bangkok
Chulalongkorn University
Pardthaisong, Tieng
Thailand, Bangkok
Chulalongkorn University
Charoeniam, Viruch
Thailand, Bangkok
Chulalongkorn University
Theetranont, Choti
Thailand, Bangkok
Chulalongkorn University
Boosiri, Banpot
Australia, Sydney
The University of Sydney
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Chutivongse, Supawat
Thailand, Bangkok
Siriraj Hospital
Switzerland, Geneva
Université de Genève Faculté de Médecine
Virutamasen, Pramuan
Australia, Sydney
The University of Sydney
United States, Louisville
University of Louisville Health Sciences Center
Wongsrichanalai, Chansuda
Australia, Sydney
The University of Sydney
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Sindhavananda, Sermsri
Australia, Sydney
The University of Sydney
Chile, Santiago
Facultad de Medicina de la Universidad de Chile
Chile, Santiago
Hospital Del Salvador
Koetsawang, Suporn
Australia, Sydney
The University of Sydney
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Rachawat, Daungdao
Australia, Sydney
The University of Sydney
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Koetsawang, Amorn
Australia, Sydney
The University of Sydney
China, Shanghai
Shanghai Institute of Planned Parenthood Research
Riotton, Gustave
Australia, Sydney
The University of Sydney
Colombia, Cali
Hospital Universitario
Christopherson, William M.
United States, Houston
Baylor College of Medicine
Melnick, Joseph L.
United States, Seattle
Fred Hutchinson Cancer Research Center
Adam, Ervin
United States, Seattle
Fred Hutchinson Cancer Research Center
Thomas, David B.
Switzerland, Geneva
Organisation Mondiale de la Santé
Ray, Roberta M.
Switzerland, Geneva
Organisation Mondiale de la Santé
Noonan, Elizabeth A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Stanford, Janet L.
Switzerland, Geneva
Organisation Mondiale de la Santé
Rosenblatt, Karin A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Holck, Susan E.
United States, Seattle
Fred Hutchinson Cancer Research Center
Meirik, Olav
United States, Seattle
Fred Hutchinson Cancer Research Center
Farley, Timothy M.M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Thomas, David B.
United States, Seattle
Fred Hutchinson Cancer Research Center
Ray, Roberta M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Statistics
Citations: 59
Authors: 59
Affiliations: 18
Identifiers
Doi:
10.1002/ijc.2910550211
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer
Health System And Policy
Sexual And Reproductive Health
Participants Gender
Female