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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Molecular analysis of the association of HLA-B53 and resistance to severe malaria
Nature, Volume 360, No. 6403, Year 1992
Notification
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Description
The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component. © 1992 Nature Publishing Group.
Authors & Co-Authors
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
Elvin, John G.
United Kingdom, Oxford
University of Oxford
Willis, Antony C.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Aidoo, Michael A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Allsopp, Catherine E.M.
United Kingdom, Oxford
University of Oxford
Gotch, Frances M.
United Kingdom, Oxford
University of Oxford
Ming Gao, X.
United Kingdom, Oxford
University of Oxford
Takiguchi, Masafumi
Japan, Tokyo
The University of Tokyo
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Townsend, Alain R.M.
United Kingdom, Oxford
University of Oxford
McMichael, Andrew James
United Kingdom, Oxford
University of Oxford
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 674
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1038/360434a0
ISSN:
00280836
Research Areas
Infectious Diseases