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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Plasmodium falciparum infection during dry season: IgG responses to Anopheles gambiae salivary gSG6-P1 peptide as sensitive biomarker for malaria risk in Northern Senegal
Malaria Journal, Volume 12, No. 1, Article 301, Year 2013
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Description
Background: The Northern part of Senegal is characterized by a low and seasonal transmission of malaria. However, some Plasmodium falciparum infections and malaria clinical cases are reported during the dry season. This study aims to assess the relationship between IgG antibody (Ab) responses to gSG6-P1 mosquito salivary peptide and the prevalence of P. falciparum infection in children during the dry season in the Senegal River Valley. The positive association of the Ab response to gSG6-P1, as biomarker of human exposure to Anopheles vector bite, and P. falciparum infectious status (uninfected, infected-asymptomatic or infected-symptomatic) will allow considering this biomarker as a potential indicator of P. falciparum infection risk during the dry season. Methods. Microscopic examination of thick blood smears was performed in 371 and 310 children at the start (January) and at the end (June) of the dry season, respectively, in order to assess the prevalence of P. falciparum infection. Collected sera were used to evaluate IgG response to gSG6-P1 by ELISA. Association between parasitological and clinical data (infected-asymptomatic or infected-symptomatic) and the anti-gSG6-P1 IgG levels were evaluated during this period. Results: The prevalence of P. falciparum infection was very low to moderate according to the studied period and was higher in January (23.5%) compared to June (3.5%). Specific IgG response was also different between uninfected children and asymptomatic carriers of the parasite. Children with P. falciparum infection in the dry season showed higher IgG Ab levels to gSG6-P1 than uninfected children. Conclusions: The results strengthen the hypothesis that malaria transmission is maintained during the dry season in an area of low and seasonal transmission. The measurement of IgG responses to gSG6-P1 salivary peptide could be a pertinent indicator of human malaria reservoir or infection risk in this particular epidemiological context. This promising immunological marker could be useful for the evaluation of the risk of P. falciparum exposure observed during dry season and, by consequences, could be used for the survey of potential pre-elimination situation. © 2013 Sagna et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3766161/bin/1475-2875-12-301-S1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3766161/bin/1475-2875-12-301-S2.tiff
Authors & Co-Authors
Sagna, André Barembaye
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Gaayeb, Lobna
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Lille
Center for Infection and Immunity of Lille Ciil
Sarr, Jean B.
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Montpellier
Ird Centre de Montpellier
Senghor, Simon
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Poinsignon, Anne
France, Montpellier
Ird Centre de Montpellier
Boutouaba-Combe, Samy
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
Schacht, Anne Marie
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Lille
Center for Infection and Immunity of Lille Ciil
Hermann, Emmanuel
France, Lille
Center for Infection and Immunity of Lille Ciil
Faye, Ngor
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Remoué, Franck J.
France, Montpellier
Ird Centre de Montpellier
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Riveau, Gilles J.
Senegal, Saint-louis
Centre de Recherche Biomédicale Espoir Pour la Santé Crb-epls
France, Lille
Center for Infection and Immunity of Lille Ciil
Statistics
Citations: 11
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1186/1475-2875-12-301
e-ISSN:
14752875
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Senegal