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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Changes in antioxidant status and biochemical parameters after orally cadmium administration in females rats
Acta Biologica Hungarica, Volume 60, No. 1, Year 2009
Notification
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Description
The research was conducted to investigate the toxic effects of cadmium chloride (CdCl2), administered during gestation period on female Wistar rats. Pregnant rats received CdCl2 (20 mg/l, orally) from Day 6 to Day 19 of pregnancy. Results showed that Cd treatment induced a decrease in body weight gain. The relative liver weight increased significantly, with a marked decrease of glycogen and total lipids content. The administration of Cd induced hepatotoxicity as indicated by elevations in plasma alanine aminotransferase (ALT), aspartate aminotransferase and lactate dehydrogenase (LDH) activities (p < 0.05). Treatment with CdCl2 caused a significant (p < 0.05) increase in glucose. A significant increase was observed in the level of MDA and 8-oxodGuo tissues in the cadmium-exposed group compared to the control group (p < 0.05). Results showed that cadmium given to dams led to an oxidative stress and DNA damage in tissues of pregnant rats. © 2009 Akadémiai Kiadó.
Authors & Co-Authors
Chater, Sihem
Tunisia, Tunis
University of Carthage
France, Grenoble
Cea Grenoble
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Douki, Thierry
France, Grenoble
Cea Grenoble
Favier, Alain Emile
France, Grenoble
Cea Grenoble
France, La Tronche
Hôpital de la Tronche Chu Grenoble
Sakly, Mohsen
Tunisia, Tunis
University of Carthage
Abdelmelek, Hafedh
Tunisia, Tunis
University of Carthage
Statistics
Citations: 22
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1556/ABiol.60.2009.1.8
ISSN:
02365383
e-ISSN:
1588256X
Research Areas
Environmental
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Female