Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis
Breast Cancer Research and Treatment, Volume 126, No. 1, Year 2011
Notification
URL copied to clipboard!
Description
C-terminal tensin-like (CTEN) gene is a member of the TENSIN gene family, involved in cell migration and localised at focal adhesion sites. This study was designed to explore the prevalence and clinical significance of CTEN expression in a large and well-characterised series (n = 1,409) invasive breast cancer (BC) cases with long term follow-up (median 11 years), using immunohistochemistry and tissue microarray. Moderate to strong cytoplasmic immunoreactivity for CTEN was observed in 90% of the studied cases. CTEN expression was significantly associated with poor prognostic variables including larger tumour size (P = 0.044), higher histological grade (P = 0.019), axillary nodal involvement (P = 0.035) and poor Nottingham Prognostic Index (P = 0.016). Significant associations were observed between increased CTEN expression and up-regulation of phosphorylated-Akt (P-Akt), PIK3 and N-cadherin proteins (P < 0.001). Kaplan-Meier survival analysis demonstrated that patients with high CTEN expression had significantly shorter Breast Cancer Specific Survival (P = 0.004) and Metastasis-Free Survival (P = 0.041) than those with low-CTEN expression. Multivariate analysis showed that CTEN was not an independent prognostic marker in BC. In conclusion, our results demonstrated the oncogenetic role of increased CTEN expression and its association with poor prognostic parameters. These data could help in prognostic assessment in BC patients. © 2010 Springer Science+Business Media, LLC.
Authors & Co-Authors
Albasri, Abdulkader Mohammed
United Kingdom, Nottingham
University of Nottingham
Saudi Arabia
University of Tibah
Aleskandarany, Mohammed A.
United Kingdom, Nottingham
University of Nottingham
Benhasouna, Ahmed A.
United Kingdom, Nottingham
University of Nottingham
Powe, Desmond George
United Kingdom, Nottingham
University of Nottingham
Ellis, Ian O.
United Kingdom, Nottingham
University of Nottingham
Ilyas, Mohammad
United Kingdom, Nottingham
University of Nottingham
Green, Andew R.
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 48
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1007/s10549-010-0890-3
ISSN:
01676806
e-ISSN:
15737217
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study