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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Alternating chemo-radiotherapy with cisplatin and 5-fluorouracil plus bleomycin by continuous infusion for locally advanced undifferentiated carcinoma nasopharyngeal type
European Journal of Cancer, Volume 28, No. 11, Year 1992
Notification
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Description
More than 80% of undifferentiated carcinoma nasopharyngeal type patients with N3 disease (AJC-UICC 1987) will die with or from distant metastases within 3 years after the first symptom. From February 1986 to November 1987 30 consecutive patients with very advanced local disease were entered in a programme with chemotherapy-radiotherapy (CT-RT) alternation after a thorough work-up to eliminate the possibility of distant metastases. Protocol: two cycles of cisplatin 100 mg/m2 day 1, bleomycin 15 mg intravenously day 1 and 16 mg/m2 per day by continuous infusion days 1-5; 5-fluorouracil (5-FU) 650 mg/m2 per day by continuous infusion days 1-5 4 weeks apart. This was followed by two series of high-energy radiotherapy, 35 Gy/3.5 weeks, with a third chemotherapy cycle in between. 27 men and 3 women were treated, the median age was 37 years (range 17-71) and the mean WHO performance status was 1 (range 0-3). TNM classification: 15 T4, 9 T3, 6 T2, 28 N3 and 2 N2c. 18 patients had nodes larger than 8 cm and 24 had bulky bilateral cervical nodes. Toxicity for this protocol was moderate, nausea and vomiting being the main side-effects. Results after two CT cycles were 3 complete responses (CR; 10%), 22 partial responses (PR; 73%), 2 disease stabilisations, 2 progressions, and 1 patient inevaluable. Of the 30 patients, 27 patients completed the CT-RT protocol, 2 patients died before radiotherapy and 1 refused treatment after 2 days on protocol. 25 patients were in CR 3 months after the end of radiotherapy. As of August 1991, with a median follow-up of 55 months (range 43-63), there are 17 patients alive, 2 of them with active disease and 15 are NED (2 after salvage therapy). © 1992.
Authors & Co-Authors
Azli, Nasser
Algeria, Constantine
C.a.c. Benbadis
Armand, Jean Pierre
France, Villejuif
Institut de Cancerologie Gustave Roussy
Rahal, Mohammed Mahmoud
Algeria, Constantine
C.a.c. Benbadis
Wibault, Pierre
France, Villejuif
Institut de Cancerologie Gustave Roussy
Boussen, Hamouda
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Eschwège, Franiçois R.
France, Villejuif
Institut de Cancerologie Gustave Roussy
Schwaab, Guy
France, Villejuif
Institut de Cancerologie Gustave Roussy
Gasmi, Jamal
France, Villejuif
Institut de Cancerologie Gustave Roussy
Bachouchi, Mounir
France, Villejuif
Institut de Cancerologie Gustave Roussy
Cvitkovic, Esteban
France, Villejuif
Institut de Cancerologie Gustave Roussy
Statistics
Citations: 40
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/0959-8049(92)90005-M
ISSN:
09598049
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Participants Gender
Male
Female