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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Seroepidemiological study reveals regional co-occurrence of Lassa- and Hantavirus antibodies in Upper Guinea, West Africa
Tropical Medicine and International Health, Volume 18, No. 3, Year 2013
Notification
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Description
Objectives: To assess the public health relevance of Lassa arenavirus and hantavirus infections in a subpopulation of recently febrile patients. Methods: In a human seroprevalence study, we enrolled 253 participants on the basis of reported high fever during the last 3 months. They represented roughly 20% of the population of Bantou and Tanganya villages. Comprehensive serological screening and confirmatory assays (enzyme-linked immunosorbent assay, immunofluorescence assay, Western blot analysis) with several Lassa virus and hantavirus antigens were used to ensure high specificity and broad detection capacity. Results: We found a Lassa IgG prevalence of 40.3% (102/253) and a hantavirus IgG prevalence of 1.2% (3/253). The Lassa IgM prevalence reached 2.8% (7/253). Conclusions: High Lassa virus seroprevalence in recently febrile patients indicates that Lassa fever is a significant public health problem in the region. Human hantavirus infections also occur in the region but their public health relevance remains to be determined. © 2012 Blackwell Publishing Ltd.
Authors & Co-Authors
Klempa, Boris
Germany, Berlin
Charité – Universitätsmedizin Berlin
Slovakia, Bratislava
Institute of Virology Slovak Academy of Sciences
Koulémou, Kékoura
Guinea, Conakry
Université de Conakry
Auste, Brita
Germany, Berlin
Charité – Universitätsmedizin Berlin
Emmerich, Petra
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Thomé-Bolduan, Corinna
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Günther, Stephan
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Koivogui, Lamine
Guinea, Conakry
Université de Conakry
Kruger, Detlev H.
Germany, Berlin
Charité – Universitätsmedizin Berlin
Fichet-Calvet, Elisabeth
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Statistics
Citations: 26
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1111/tmi.12045
ISSN:
13602276
e-ISSN:
13653156
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Guinea