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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Role of V1V2 and other human immunodeficiency virus type 1 envelope domains in resistance to autologous neutralization during clade C infection
Journal of Virology, Volume 81, No. 3, Year 2007
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Description
Biologically functional clade C envelope (Env) glycoproteins from the chronically (donor) and newly (recipient) infected partners of four heterosexual transmission pairs in Zambia were cloned and characterized previously. In each case, the donor viral quasispecies contained Envs that were resistant to autologous neutralization by contemporaneous plasma, while the recipient Envs were sensitive to neutralizing antibodies in this donor plasma sample. The donor Envs also varied in length, glycosylation, and amino acid sequence of the V1V2 hypervariable domain of gp120, while the recipient Envs were much more homogeneous. To assess the contribution of V1V2 to the neutralization phenotype of the donor Envs, V1V2 domains from neutralization-sensitive recipient Envs were replaced with donor V1V2 domains, and the autologous neutralization sensitivities of the chimeric Envs were evaluated using a virus-pseudotyping assay. Long donor V1V2 domains regulated sensitivity to autologous neutralization, although the effect was dependent on the Env background. Short donor V1V2 domains did not confer neutralization resistance. Primary sequence differences in V2 were also found to influence neutralization sensitivity in one set of recipient Envs. The results demonstrate that expansion of the V1V2 domain is one pathway to escape from autologous neutralization in subtype C Envs. However, V1V2-independent mechanisms of resistance also exist, suggesting that escape is multifaceted in chronic subtype C infection. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Rong, Rong
United States, Atlanta
Emory University
Bibollet-Ruche, Frédéric
United States, Birmingham
The University of Alabama at Birmingham
Mulenga, Joseph
Zambia, Lusaka
Zambia Blood Transfusion Service
Allen, Susan A.
United States, Atlanta
Emory University
United States, Atlanta
Rollins School of Public Health
Blackwell, Jerry L.
United States, Atlanta
Emory University
Derdeyn, Cynthia A.
United States, Atlanta
Emory University
Statistics
Citations: 26
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.01839-06
ISSN:
0022538X
Study Locations
Zambia