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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Acute hyperglycemia reduces myocardial blood flow reserve and the magnitude of reduction is associated with insulin resistance: A study in nondiabetic humans using contrast echocardiography
Heart and Vessels, Volume 28, No. 6, Year 2013
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Description
The effect of acute hyperglycemia per se on coronary perfusion in humans is undefined. We evaluated the effects of short-term hyperglycemia on myocardial blood flow reserve (MBFR) in healthy nondiabetic volunteers. Twenty-one nondiabetic volunteers (76 % females, mean ± SD, age 48 ± 5 years) had noninvasive MBFR assessment while exposed to pancreatic clamp with somatostatin and replacement glucagon and growth hormone infusions, with frequent interval plasma glucose (PG) monitoring. Insulin was infused at 0.75 mU/kg/min to mimic postprandial plasma insulin concentrations, and glucose was infused to maintain euglycemia (PG 93.9 ± 7.3 mg/dl) followed by hyperglycemia (PG 231.5 ± 18.1 mg/dl). Myocardial contrast echocardiography (MCE) was performed during each glycemic steady state using continuous infusion of Definity at rest and during regadenoson (Lexiscan 5 ml (400 μg) intravenous bolus) infusion to quantify myocardial blood flow (MBF) and determine MBFR. Insulin resistance (IR) was assessed by glucose infusion rate (GIR; mg/kg/min) at euglycemia. Median stress MBF, MBFR, and β reserve were significantly reduced during acute hyperglycemia versus euglycemia (stress MBF 3.9 vs 5.4, P = 0.02; MBFR 2.0 vs 2.7, P < 0.0001; β reserve 1.45 vs 2.4, P = 0.007). Using a median threshold GIR of 5 mg/kg/min, there was a correlation between GIR and hyperglycemic MBFR (r = 0.506, P = 0.019). MBFR, as determined noninvasively by MCE, is significantly decreased during acute hyperglycemia in nondiabetic volunteers, and the magnitude of this reduction is modulated by IR. © 2012 Springer Japan.
Authors & Co-Authors
Abdelmoneim, Sahar S.
United States, Rochester
Mayo Clinic
Egypt, Asyut
Assiut University
Hagen, Mary E.
United States, Rochester
Mayo Clinic
Mendrick, Edward
United States, Rochester
Mayo Clinic
Pattan, Vishwanath
United States, Rochester
Mayo Clinic
Wong, Benjamin
United States, Rochester
Mayo Clinic
Norby, Barbara
United States, Rochester
Mayo Clinic
Roberson, Tamara
United States, Rochester
Mayo Clinic
Szydel, Troy
United States, Rochester
Mayo Clinic
Basu, Rita
United States, Rochester
Mayo Clinic
Basu, Ananda
United States, Rochester
Mayo Clinic
Mulvagh, Sharon L.
United States, Rochester
Mayo Clinic
Statistics
Citations: 11
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1007/s00380-012-0305-y
ISSN:
09108327
e-ISSN:
16152573
Participants Gender
Female