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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Carriage of Blastocystis spp. in travellers - A prospective longitudinal study
Travel Medicine and Infectious Disease, Volume 27, Year 2019
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Description
Introduction: A lack of prospective and longitudinal data on pre- and post-travel carriage of Blastocystis spp. complicates interpretation of a positive test post-travel. Therefore we studied dynamics of Blastocystis carriage in a cohort of Dutch travellers. Methods: From the prospective, multicentre COMBAT study among 2001 Dutch travellers, a subset of 491 travellers was selected based on travel destination to 7 subregions (70 or 71 travellers each). Faecal samples taken directly before and after travel were screened for Blastocystis with qPCR, followed, when positive, by sequence analysis to determine subtypes. Results: After exclusion of 12 samples with missing samples or inhibited qPCR-reactions, stool samples of 479 travellers were analysed. Before travel, 174 of them (36.3%) carried Blastocystis and in most of these, the same subtype was persistently carried. However, in 48/174 of those travellers (27.6%; CI95 20.8–36.6%) no Blastocystis or a different subtype was detected in the post-travel sample, indicating loss of Blastocystis during travel. Only 26 (5.4%; CI95 3.7%–8.0%) of all travellers acquired Blastocystis, including two individuals that were already positive for Blastocystis before travel but acquired a different subtype during travel. Discussion: This study shows that Blastocystis carriage in travellers is highly dynamic. The observed acquisition and loss of Blastocystis could either be travel-related or reflect the natural course of Blastocystis carriage. We demonstrate that the majority of Blastocystis detected in post-travel samples were already carried before travel. © 2018 The Authors
Authors & Co-Authors
Schultsz, Constance
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Verhaar, Nienke
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Rebers, Sjoerd P.H.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Goorhuis, Abram
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Grobusch, Martín Peter
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Penders, John
Netherlands, Maastricht
Universiteit Maastricht
De Jong, Menno Douwe
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Gool, Tom
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Bart, Aldert
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van Genderen, Perry J.J.
Unknown Affiliation
Oude Lashof, Astrid M.L.
Netherlands, Maastricht
Universiteit Maastricht
Stobberingh, Ellen E.
Netherlands, Maastricht
Universiteit Maastricht
Verbrugh, Henri A.
Netherlands, Rotterdam
Erasmus Mc
Statistics
Citations: 12
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1016/j.tmaid.2018.06.005
ISSN:
14778939
Study Design
Cohort Study
Study Approach
Quantitative