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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Assessing the use of minimally invasive self-sampling at home for long-term monitoring of the microbiota within UK families
Scientific Reports, Volume 13, No. 1, Article 18201, Year 2023
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Description
Monitoring the presence of commensal and pathogenic respiratory microorganisms is of critical global importance. However, community-based surveillance is difficult because nasopharyngeal swabs are uncomfortable and painful for a wide age range of participants. We designed a methodology for minimally invasive self-sampling at home and assessed its use for longitudinal monitoring of the oral, nasal and hand microbiota of adults and children within families. Healthy families with two adults and up to three children, living in and near Liverpool, United Kingdom, self-collected saliva, nasal lining fluid using synthetic absorptive matrices and hand swabs at home every two weeks for six months. Questionnaires were used to collect demographic and epidemiological data and assess feasibility and acceptability. Participants were invited to take part in an exit interview. Thirty-three families completed the study. Sampling using our approach was acceptable to 25/33 (76%) families, as sampling was fast (76%), easy (76%) and painless (60%). Saliva and hand sampling was acceptable to all participants of any age, whereas nasal sampling was accepted mostly by adults and children older than 5 years. Multi-niche self-sampling at home can be used by adults and children for longitudinal surveillance of respiratory microorganisms, providing key data for design of future studies. © 2023, Springer Nature Limited.
Authors & Co-Authors
Nikolaou, Elissavet
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Australia, Melbourne
Murdoch Children's Research Institute
Australia, Melbourne
University of Melbourne
German, Esther L.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Howard, Ashleigh
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Nabwera, Helen M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Liverpool
Alder Hey Children's Hospital
Pakistan, Karachi
The Aga Khan University
Matope, Agnes
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Robinson, Ryan E.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
Shiham, Farah
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Liatsikos, Konstantinos
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
Parry, Christopher Mark
United Kingdom, Liverpool
Alder Hey Children's Hospital
Allen, Stephen John
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Gambia, Banjul
Royal Victoria Teaching Hospital Gambia
Urban, Britta Christina
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Oxford
University of Oxford
Hawcutt, Daniel B.
United Kingdom, Liverpool
Alder Hey Children's Hospital
United Kingdom, Liverpool
University of Liverpool
Hill, Helen C.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Collins, Andrea M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Liverpool
Liverpool University Hospitals Nhs Foundation Trust
Ferreira, Daniela Mulari
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Oxford
University of Oxford
Statistics
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1038/s41598-023-45574-6
ISSN:
20452322
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study