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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Triple co-administration of ivermectin, albendazole and praziquantel in Zanzibar: A safety study
PLoS Neglected Tropical Diseases, Volume 2, No. 1, Article e171, Year 2008
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Description
Background: Public health interventions based on distribution of anthelminthic drugs against lymphatic filariasis (LF). onchocerciasis, soil-transmitted helminthiasis (STH) and schistosomiasis have been implemented separately to date. A better use of available resources might be facilitated by a more coordinated approach to control such infections, including the possibility of co-administering the three-recommended anthelminthic drugs through a single, large-scale intervention. Methodology/Principal Findings: Ivermectin, albendazole and praziquantel were co-administered to 5,055 children and adults living in areas endemic for LF, STH and schistosomiasis in Zanzibar, United Republic of Tanzania, during a pilot intervention aimed at elucidating and quantifying possible side-effects. Subsequently, these drugs were co-administered to about 700,000 individuals during a countrywide intervention targeting a large part of the total population of Zanzibar. Passive and active surveillance measures carried out during both interventions showed that side-effects attributable to the three drugs given at the same time were mild and self-limiting events. Conclusions/Significance: Our data suggest that co-administration of ivermectin, albendazole and praziquantel is safe in areas where lymphatic filariasis, soil-transmitted helminthiasis and schistosomiasis are co-endemic and where several rounds of treatment with one or two drugs have been implemented in the past. Passive surveillance measures, however, should be continued and detection, management and reporting of possible side-effects should be considered a key component of any health intervention administering drugs. © 2008 Mohammed et al.
Authors & Co-Authors
Mohammed, Khalfan Abdallah
Tanzania, Mkokotoni
Ministry of Health Zanzibar
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Haji, Hamadi Juma
Tanzania, Mkokotoni, Zanzibar
Public Health Laboratory-ivo de Carneri
Gabrielli, Albis Francesco
Switzerland, Geneva
Organisation Mondiale de la Santé
Mubila, Likezo
Zimbabwe, Harare
Who Regional Office for Africa
Biswas, Gautam
Switzerland, Geneva
Organisation Mondiale de la Santé
Chitsulo, Lester A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Bradley, Mark H.
United Kingdom, Brentford
Glaxosmithkline Plc.
Engels, Dirk A.
Switzerland, Geneva
Organisation Mondiale de la Santé
Savioli, Lorenzo
Switzerland, Geneva
Organisation Mondiale de la Santé
Molyneux, David Hurst
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 69
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pntd.0000171
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Tanzania