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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
SARS-CoV-2 spike D614G change enhances replication and transmission
Nature, Volume 592, No. 7852, Year 2021
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Description
During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike glycoprotein (S) has emerged; virus containing this substitution has become the predominant circulating variant in the COVID-19 pandemic1. However, whether the increasing prevalence of this variant reflects a fitness advantage that improves replication and/or transmission in humans or is merely due to founder effects remains unknown. Here we use isogenic SARS-CoV-2 variants to demonstrate that the variant that contains S(D614G) has enhanced binding to the human cell-surface receptor angiotensin-converting enzyme 2 (ACE2), increased replication in primary human bronchial and nasal airway epithelial cultures as well as in a human ACE2 knock-in mouse model, and markedly increased replication and transmissibility in hamster and ferret models of SARS-CoV-2 infection. Our data show that the D614G substitution in S results in subtle increases in binding and replication in vitro, and provides a real competitive advantage in vivo—particularly during the transmission bottleneck. Our data therefore provide an explanation for the global predominance of the variant that contains S(D614G) among the SARS-CoV-2 viruses that are currently circulating. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
Authors & Co-Authors
Zhou, Bin
United States, Atlanta
Centers for Disease Control and Prevention
Hoffmann, Donata
Germany, Tubingen
Friedrich-loeffler-institute
Taddeo, Adriano
Switzerland, Mittelhausen
Institut Für Viruskrankheiten Und Immunprophylaxe
Switzerland, Zurich
Vetsuisse-fakultät
Labroussaa, Fabien
Switzerland, Zurich
Vetsuisse-fakultät
Pohlmann, Anne
Germany, Tubingen
Friedrich-loeffler-institute
King, Jacqueline
Germany, Tubingen
Friedrich-loeffler-institute
Portmann, Jasmine
Switzerland, Mittelhausen
Institut Für Viruskrankheiten Und Immunprophylaxe
Switzerland, Zurich
Vetsuisse-fakultät
Halwe, Nico Joel
Germany, Tubingen
Friedrich-loeffler-institute
Hoffmann, Bernd
Germany, Tubingen
Friedrich-loeffler-institute
de Brot, Simone
Switzerland, Bern
University of Bern, Institute of Animal Pathology
Wilson, Malania M.
United States, Atlanta
Centers for Disease Control and Prevention
Keller, Matthew W.
United States, Atlanta
Centers for Disease Control and Prevention
Barnes, John R.
United States, Atlanta
Centers for Disease Control and Prevention
Dijkman, Ronald
Switzerland, Mittelhausen
Institut Für Viruskrankheiten Und Immunprophylaxe
Switzerland, Zurich
Vetsuisse-fakultät
Switzerland, Bern
University of Bern
Jores, Joerg
Switzerland, Zurich
Vetsuisse-fakultät
Wentworth, David E.
United States, Atlanta
Centers for Disease Control and Prevention
Thiel, Volker
Switzerland, Mittelhausen
Institut Für Viruskrankheiten Und Immunprophylaxe
Switzerland, Zurich
Vetsuisse-fakultät
Beer, Martin
Germany, Tubingen
Friedrich-loeffler-institute
Statistics
Citations: 313
Authors: 18
Affiliations: 8
Identifiers
Doi:
10.1038/s41586-021-03361-1
ISSN:
00280836
Research Areas
Covid
Study Design
Cross Sectional Study