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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon
Scientific Reports, Volume 13, No. 1, Article 21654, Year 2023
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Description
While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2022 in Cameroon. Of the 760 whole-genome sequences successfully generated by the national genomic surveillance network, 74% were viral sub-lineages of origin and non-variants of concern, 15% Delta, 6% Omicron, 3% Alpha and 2% Beta variants. The pandemic was driven by SARS-CoV-2 lineages of origin in wave 1 (16 weeks, 2.3% CFR), the Alpha and Beta variants in wave 2 (21 weeks, 1.6% CFR), Delta variants in wave 3 (11 weeks, 2.0% CFR), and omicron variants in wave 4 (8 weeks, 0.73% CFR), with a declining trend over time (p = 0.01208). Even though SARS-CoV-2 heterogeneity did not seemingly contribute to the breadth of transmission, the viral lineages of origin and especially the Delta variants appeared as drivers of COVID-19 severity in Cameroon. © 2023, The Author(s).
Authors & Co-Authors
Fokam, Joseph
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Cameroon, Buea
University of Buea
Essomba, Rene Ghislain
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
Njouom, Richard
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Centre Pasteur du Cameroun
Okomo, Marie Claire Assoumou
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
Eyangoh, Sara Irène
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Centre Pasteur du Cameroun
Godwe, Célestin
Cameroon, Yaounde
Centre de Recherche en Maladies Emergentes et Re-emergentes Cremer
Tegomoh, Bryan
United States, Berkeley
University of California, Berkeley
Otshudiema, John Otokoye
Switzerland, Geneva
Organisation Mondiale de la Santé
Nwobegahay, Julius Mbekem
Cameroon, Yaounde
Ministry of Public Health Cameroon
Ndip, Lucy Mande
Cameroon, Buea
University of Buea
Akenji, Blaise
Cameroon, Yaounde
Ministry of Public Health Cameroon
Takou, Désiré Komego
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Ndze, Valentine Ngum
Cameroon, Buea
University of Buea
Maidadi-Foudi, Martin
Cameroon, Yaounde
Centre de Recherche en Maladies Emergentes et Re-emergentes Cremer
Kouanfack, Charles
Cameroon, Yaounde
Centre de Recherche en Maladies Emergentes et Re-emergentes Cremer
Ngono, Dorine
United States, Berkeley
University of California, Berkeley
N’kengasong, John Nkemngong
Unknown Affiliation
Ndembi, Nicaise N.
Unknown Affiliation
Bissek, Anne Cécile Zoung Kanyi
Cameroon, Buea
University of Buea
Cameroon, Yaounde
Ministry of Public Health Cameroon
Ndongo, Chanceline Bilounga
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Douala
University of Douala
Epée, Émilienne E.E.
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
Mandeng, Nadia
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Bamenda
University of Bamenda
Ayouba, Ahidjo
France, Montpellier
Ird Centre de Montpellier
Tongo, Marcel
Cameroon, Yaounde
Centre de Recherche en Maladies Emergentes et Re-emergentes Cremer
Colizzi, Vittorio C.
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Halle-Ekane, Gregory Edie
Cameroon, Buea
University of Buea
Perno, Carlo Federico
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Italy, Rome
Irccs Ospedale Pediatrico Bambino Gesù
Ndjolo, Alexis
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Cameroon, Yaounde
Université de Yaoundé I
Ndongmo, Clement Bertin
Cameroon, Yaounde
Center for Diseases Control and Prevention
Shang, Judith D.
Cameroon, Yaounde
Center for Diseases Control and Prevention
Esso, Linda
Cameroon, Yaounde
Ministry of Public Health Cameroon
Diagne, Moussa Moïse
Senegal, Dakar
Institut Pasteur de Dakar
Boum, Yap I.
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
France, Paris
Epicentre
Mballa, Georges Alain Etoundi
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
Njock, Richard L.
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Douala
University of Douala
Mba, Serge Alain Sadeuh
Cameroon, Yaounde
Centre Pasteur du Cameroun
Henri, Moumbeket Yifomnjou Moise
Cameroon, Yaounde
Centre Pasteur du Cameroun
Beloumou, Grâce Angong
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Ngaba, Guy Pascal
Cameroon, Yaounde
Ministry of Public Health Cameroon
Amougou-Atsama, Marie
Cameroon, Yaounde
Ministry of Public Health Cameroon
Mouliom, Abas
Cameroon, Yaounde
Ministry of Public Health Cameroon
Nka, Alex Durand
Cameroon, Yaounde
Ministry of Public Health Cameroon
Cameroon, Yaounde
Chantal Biya International Reference Centre for Research on Hiv/aids Prevention and Management Circb
Dimite, Laura E.
Cameroon, Yaounde
Center for Diseases Control and Prevention
Eboumbou, Carole E.
Cameroon, Douala
University of Douala
Statistics
Authors: 44
Affiliations: 17
Identifiers
Doi:
10.1038/s41598-023-48773-3
ISSN:
20452322
Research Areas
Covid
Genetics And Genomics
Study Locations
Cameroon