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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Consanguinity and increased risk for schizophrenia in Egypt
Schizophrenia Research, Volume 120, No. 1-3, Year 2010
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Description
Background: Consanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are unavailable. Our recent studies in Egypt have shown elevated parental consanguinity rates among patients with bipolar I disorder (BP1), compared with controls. We have now extended our analyses to schizophrenia (SZ) in the same population. Methods: A case-control study was conducted at Mansoura University Hospital, Mansoura, Egypt (SZ, n=75; controls, n=126, and their available parents). The prevalence of consanguinity was estimated from family history data ('self report'), followed by DNA analysis using short tandem repeat polymorphisms (STRPs, n=63) ('DNA-based' rates). Results: Self-reported consanguinity was significantly elevated among the patients (SZ: 46.6%, controls: 19.8%, OR 3.53, 95% CI 1.88, 6.64; p=0.000058, 1 d.f.). These differences were confirmed using DNA-based estimates for coefficients of inbreeding (inbreeding coefficients as means ± standard error, cases: 0.058 ± 0.007, controls: 0.022 ± 0.003). Conclusions: Consanguinity rates are signifcantly elevated among Egyptian SZ patients in the Nile delta region. The associations are similar to those observed with BP1 in our earlier study. If replicated, the substantial risk associated with consanguinity raises public health concerns. They may also pave the way for gene mapping studies. © 2010 Elsevier B.V.
Authors & Co-Authors
Mansour, Hader A.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Egypt, Mansoura
Faculty of Medicine
Fathi, Warda
Egypt, Mansoura
Faculty of Medicine
Klei, Lambertus
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Wood, Joel A.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Chowdari, Kodavali Venkat
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Watson, Annie
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Eissa, Ahmed Ibrahim
Egypt, Mansoura
Faculty of Medicine
Elassy, Mai
Egypt, Mansoura
Faculty of Medicine
Ali, Ibtihal
Egypt, Mansoura
Faculty of Medicine
Salah, Hala
Egypt, Mansoura
Faculty of Medicine
Yassin, Amal
Egypt, Mansoura
Faculty of Medicine
Tobar, Salwa Salah
Egypt, Mansoura
Faculty of Medicine
El-Boraie, Hala Ahmed
Egypt, Mansoura
Faculty of Medicine
Gaafar, Hanan
Egypt, Mansoura
Faculty of Medicine
Ibrahim, Nahed E.
United States, Pittsburgh
Upmc Western Psychiatric Hospital
Kandil, Kareem
United States, Pittsburgh
Upmc Western Psychiatric Hospital
El-Bahaei, Wafaa
Egypt, Mansoura
Faculty of Medicine
El-Boraie, Osama A.
Egypt, Mansoura
Faculty of Medicine
Alatrouny, Mohamed
Egypt, Mansoura
Faculty of Medicine
El-Chennawi, Farha Abdel Aziz
Egypt, Mansoura
Faculty of Medicine
Devlin, Bernie
United States, Pittsburgh
Upmc Western Psychiatric Hospital
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Nimgaonkar, Vishwajit Laxmikant
United States, Pittsburgh
Upmc Western Psychiatric Hospital
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Statistics
Citations: 58
Authors: 22
Affiliations: 3
Identifiers
Doi:
10.1016/j.schres.2010.03.026
ISSN:
09209964
Research Areas
Genetics And Genomics
Health System And Policy
Mental Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Egypt