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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Metabolomic and ecdysteroid variations in anopheles gambiae s.l. mosquitoes exposed to the stressful conditions of the dry season in Burkina Faso, West Africa
Physiological and Biochemical Zoology, Volume 87, No. 3, Year 2014
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Description
This study explored the metabolic adjustments prompted by a switch between the rainy and dry season conditions in the African malaria mosquitoes Anopheles gambiae (M and S molecular forms) and Anopheles arabiensis. Mosquitoes were reared in contrasted experimental conditions reflecting environmental variation in Burkina Faso. Thirty-five metabolites (including sugars, polyols, and amino acids) were monitored in newly emerged males and females, and their ecdysteroid titers were determined. Metabolomic signatures were remarkablysimilar across species, when specimens of same age and sex were reared under identical experimental conditions. In males and females, amino acids (including glycine, leucine, phenylanine, serine, threonine, and valine) were accumulated in 1-h-old mosquitoes, then decreased 24 h after emergence, probably reflecting adult maturation and the amino acid-consuming process of cuticle sclerotisation. In turn, elevated amounts of alanine and proline in 24-h-old mosquitoes may assist the development of flight ability. Lower concentration of tricarboxylic acid cycle intermediates and isoleucine characterized older females reared under dry season conditions, suggesting metabolic and reproduction depression. In all cases, ecdysteroid concentration was much higher in males than in females, with significant seasonal variation in males. This might reflect a unique role of these hormones in shaping reproductive strategies and population demography in the An. gambiae s.l. species complex, further contributing to local adaptation in a highly fluctuating environment. © 2014 by The University of Chicago.
Authors & Co-Authors
Mamaï, Wadaka
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Burkina Faso, Bobo-dioulasso
Université Nazi Boni
Mouline, Karine
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Blais, Catherine
France, Versailles
Physiologie de L'insecte Signalisation et Communication
Larvor, V.
France, Rennes
Écosystèmes, Biodiversité, Évolution
Dabiré, Roch Kounbobr
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Ouédraogo, Georges Anicet
Burkina Faso, Bobo-dioulasso
Université Nazi Boni
Simard, Frédéric R.
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Renault, David
France, Rennes
Écosystèmes, Biodiversité, Évolution
Statistics
Citations: 23
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1086/675697
ISSN:
15222152
Research Areas
Infectious Diseases
Mental Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Burkina Faso
Participants Gender
Female