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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy
Microvascular Research, Volume 48, No. 2, Year 1994
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Description
Morphometric techniques were employed to assess perineurial capillary abnormalities in the sural nerve of 20 diabetic patients with neuropathy and 10 normal control subjects. Structural abnormalities were related to quantitative neurophysiological and neuropathological measures of neuropathy. Perineurial capillary endothelial cell area (P < 0.001) and endothelial cell profile number (P < 0.01) were increased and luminal area (P < 0.001) was reduced in diabetic patients when compared with control subjects. A significant relationship was observed between endothelial cell hyperplasia and measures of neuropathic severity. These findings provide evidence for perineurial capillary luminal occlusion due primarily to both endothelial cell hypertrophy and hyperplasia. Such a reduction in luminal size is expected to reduce transperineurial and hence endoneurial blood flow, resulting in endoneurial hypoxia and hence human diabetic neuropathy. © 1993 Academic Press, Inc.
Authors & Co-Authors
Malik, Rayaz Ahmed
United Kingdom, Manchester
Manchester Royal Infirmary
Tesfaye, Solomon Hailemariam
United Kingdom, Sheffield
Royal Hallamshire Hospital
Thompson, S. D.
United Kingdom, Aberdeen
University of Aberdeen
Veves, Aristidis
United Kingdom, Manchester
Manchester Royal Infirmary
Hunter, A.
United Kingdom, Aberdeen
University of Aberdeen
Sharma, A. K.
United Arab Emirates, Al Ain
United Arab Emirates University
Ward, J. D.
United Kingdom, Sheffield
Royal Hallamshire Hospital
Boulton, Andrew J.M.
United Kingdom, Manchester
Manchester Royal Infirmary
Statistics
Citations: 38
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1006/mvre.1994.1051
ISSN:
00262862
Study Approach
Quantitative