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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Plasma chitotriosidase activity in acute Plasmodium falciparum malaria
Clinica Chimica Acta, Volume 331, No. 1-2, Year 2003
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Description
Background: Chitotriosidase is a functional chitinase secreted by activated macrophages. It is encoded by a gene located on chromosome 1q31-32, whose mutations may be responsible for chitotriosidase deficiency, encountered in almost 6% of Caucasian population. Objective: This study reports firstly plasma chitotriosidase activity in African children with acute Plasmodium falciparum malaria. The chitotriosidase activity was correlated to objective parameters reflecting the status of the disease and compared with those found in healthy African children. Results: We found that plasma chitotriosidase levels are significantly increased in African children with acute malaria (185.0±141.0 nmol/h/ml; median 150; range 11-521) with respect to reference values obtained in age matched African children (84.4.5±72.8 nmol/ml/h; median 63; range 4-350) (P<0.001). Moreover the levels of chitotriosidase were higher in African children than in Caucasian children matched for age (28.86±18.7 nmol/h/ml; median 24; range 1-98) (P<0.0001). A remarkable significant correlation was found between plasma chitotriosidase and reticulo-endothelial activation, as judged by thrombocytopenia degree and serum ferritin level in children with acute malaria. Conclusion: Based on this study, it appears that genetic and environmental features might be responsible for diversity of plasma chitotriosidase activity in black children living in Burkina Faso. © 2003 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Barone, Rita
Italy, Mangone
Istituto Di Scienze Neurologiche, Mangone
Simpore, J.
Burkina Faso, Ouagadougou
Medical Center San Camille
Malaguarnera, Lucia
Italy, Catania
Università Degli Studi Di Catania
Pignatelli, Salvatore
Burkina Faso, Ouagadougou
Medical Center San Camille
Musumeci, Salvatore V.
Italy, Sassari
Università Degli Studi Di Sassari
Statistics
Citations: 81
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/S0009-8981(03)00089-5
ISSN:
00098981
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Burkina Faso