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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection
European Journal of Immunology, Volume 39, No. 11, Year 2009
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Description
Although CD1 proteins are known to present mycobacterial lipid antigens to T cells, there is little understanding of the in vivo behavior of T cells restricted by CD1a, CD1b and CD1c, and the relative immunogenicity and immunodominance of individual lipids within the total array of lipids that comprise a bacterium. Because bovines expressmultiple CD1 proteins and are natural hosts of Mycobacterium bovis and Mycobacterium avium paratuberculosis (MAP), we used them as a new animalmodel of CD1 function. Here, we report the surprisingly divergent responses against lipids produced by these two pathogens during infection. Despite considerable overlap in lipid content, only three out of 69 animals cross-react with M. bovis and MAP total lipid preparations. The unidentified immunodominant compound of M. bovis is a hydrophilic compound, whereas the immunodominant lipid of MAP is presented by CD1b and was identified as glucose monomycolate (GMM). The preferential recognition of GMM antigen by MAP-infected cattle may be explained by the higher expression of GMM by MAP than by M. bovis. The bacterial species-specific nature of the CD1-restricted, adaptive T-cell response affects the approach to development of lipid based immunodiagnostic tests. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Authors & Co-Authors
Van Rhijn, Ildiko
Netherlands, Utrecht
Universiteit Utrecht
Nguyen, Thi Kim Anh
Netherlands, Utrecht
Universiteit Utrecht
Michel, Anita Luise
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
South Africa, Pretoria
University of Pretoria
Cooper, David V.
Unknown Affiliation
Govaerts, Marc M.
Belgium, Brussels
Veterinary and Agrochemical Research Centre
Cheng, Tan Yuri
United States, Boston
Brigham and Women's Hospital
Van Eden, Willem E.
Netherlands, Utrecht
Universiteit Utrecht
Moody, David Branch
United States, Boston
Brigham and Women's Hospital
Coetzer, Jacobus Andries Wynand
South Africa, Pretoria
University of Pretoria
Rutten, Victor P.M.G.
Netherlands, Utrecht
Universiteit Utrecht
South Africa, Pretoria
University of Pretoria
Koets, Ad P.
Netherlands, Utrecht
Universiteit Utrecht
Statistics
Citations: 24
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1002/eji.200939619
e-ISSN:
15214141