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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia
Journal of Ethnopharmacology, Volume 128, No. 1, Year 2010
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Description
Ethnopharmacological relevance: Inflammations and immune-related diseases such as rheumatoid arthritis are growing global concerns. Most of the drugs from plants which have become important in modern medicine had a folklore origin and are traditional in systems of medicine. Citrullus colocynthis Schrad. (cucurbitaceae), endemic in Southern Tunisia, is used in folk medicine to treat many inflammation diseases. Aim of study: To evaluate the acute toxicity of different parts of Citrullus colocynthis and then to screen the analgesic and anti-inflammatory activities of aqueous extracts from roots and stems of the plant and from fruits and seeds at different maturation stages. Materials and methods: After identification and acute toxicity assay Citrullus colocynthis Schrad. aqueous extracts were screened for analgesic and anti-inflammatory activities using, respectively, the acetic acid writhing test in mice and the carrageenan-induced paw edema assay in rats. Results: All extracts displayed analgesic and anti-inflammatory activities at different doses without inducing acute toxicity. Topic results were obtained with immature fruits followed by seeds. The stem and root extracts were shown to possess the less significant inhibitory activity against analgesic and anti-inflammatory models. Conclusions: Based on this study, we confirmed that Citrullus colocynthis Schrad. is a potentially useful drug suitable for further evaluation for rheumatoid arthritis, and its folk medicinal use as an analgesic and anti-inflammatory agents is validated. © 2009 Elsevier Ireland Ltd.
Authors & Co-Authors
Marzouk, Belsem
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Marzouk, Zohra
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Haloui, Ehsen
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Fenina, Nadia
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Bouraoui, Abderrahman
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Aouni, Mahjoub
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 148
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.jep.2009.11.027
ISSN:
03788741
Research Areas
Health System And Policy
Study Locations
Tunisia