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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection
Journal of Immunology, Volume 191, No. 5, Year 2013
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Description
Chronic activation of T cells is a hallmark of HIV-1 infection and plays an important role in disease progression. We previously showed that the engagement of the inhibitory receptor programmed death (PD)-1 on HIV-1-specific CD4 + and CD8+ T cells leads to their functional exhaustion in vitro. However, little is known about the impact of PD-1 expression on the turnover and maturation status of T cells during the course of the disease. In this study, we show that PD-1 is upregulated on all T cell subsets, including naive, central memory, and transitional memory T cells in HIV-1-infected subjects. PD-1 is expressed at similar levels on most CD4+ T cells during the acute and the chronic phase of disease and identifies cells that have recently entered the cell cycle. In contrast, PD-1 expression is dramatically increased in CD8+ T cells during the transition from acute to chronic infection, and this is associated with reduced levels of cell proliferation. The failure to downregulate expression of PD-1 in most T cells during chronic HIV-1 infection is associated with persistent alterations in the distribution of T cell subsets and is associated with impaired responses to IL-7. Our findings identify PD-1 as a marker for aberrant distribution of T cell subsets in HIV-1 infection. Copyright © 2013 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Breton, Gaëlle
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Chomont, Nicolas
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
United States, Miami
Vaccine and Gene Therapy Institute of Florida
Takata, Hiroshi
United States, Miami
Vaccine and Gene Therapy Institute of Florida
Filali-Mouhim, Ali
United States, Miami
Vaccine and Gene Therapy Institute of Florida
Riou, Catherine
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
Boulassel, Mohamed Rachid
Canada, Montreal
Mcgill University Health Centre, Royal Victoria Hospital
Routy, Jean Pierre G.
Canada, Montreal
Mcgill University Health Centre, Royal Victoria Hospital
Canada, Montreal
Université Mcgill
Seḱaly, Rafick Pierre
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Canada, Montreal
University of Montreal
United States, Miami
Vaccine and Gene Therapy Institute of Florida
Canada, Montreal
Université Mcgill
Statistics
Citations: 66
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.4049/jimmunol.1200646
ISSN:
15506606
Research Areas
Infectious Diseases