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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Rates of HIV-1 superinfection and primary HIV-1 infection are similar in female sex workers in Uganda
AIDS, Volume 28, No. 14, Year 2014
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Description
Objective: To determine and compare the rates of HIV superinfection and primary HIV infection in high-risk female sex workers (FSWs) in Kampala, Uganda. Design: A retrospective analysis of individuals who participated in a clinical cohort study among high-risk FSWs in Kampala, Uganda. Methods: Plasma samples from HIV-infected FSWs in Kampala, Uganda were examined with next-generation sequencing of the p24 and gp41HIV genomic regions for the occurrence of superinfection. Primary HIV incidence was determined from initially HIV-uninfected FSWs from the same cohort, and incidence rate ratios were compared. Results: The rate of superinfection in these women (7/85; 3.4/100 person-years) was not significantly different from the rate of primary infection in the same population (3.7/ 100 person-years; incidence rate ratio = 0.91, P = 0.42). Seven women also entered the study dual-infected (16.5% either dual or superinfected). The women with any presence of dual infection were more likely to report sex work as their only source of income (P = 0.05), and trended to be older and more likely to be widowed (P = 0.07). Conclusions: In this cohort of FSWs, HIV superinfection occurred at a high rate and was similar to that of primary HIV infection. These results differ from a similar study of highrisk female bar workers in Kenya that found the rate of superinfection to be significantly lower than the rate of primary HIV infection. © 2014 Wolters Kluwer Health.
Authors & Co-Authors
Redd, Andrew D.
Unknown Affiliation
Ssemwanga, Deogratius
Unknown Affiliation
Vandepitte, Judith M.
Unknown Affiliation
Wendel, Sarah K.
Unknown Affiliation
Ndembi, Nicaise N.
Unknown Affiliation
Bukenya, Justine Nnakate
Unknown Affiliation
Nakubulwa, Susan
Unknown Affiliation
Grosskurth, Heiner
Unknown Affiliation
Parry, Chris M.
Unknown Affiliation
Martens, Craig A.
Unknown Affiliation
Bruno, Daniel
Unknown Affiliation
Porcella, Stephen F.
Unknown Affiliation
Quinn, Thomas Charles
Unknown Affiliation
Kaleebu, Pontiano P.
Unknown Affiliation
Statistics
Citations: 22
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1097/QAD.0000000000000365
e-ISSN:
14735571
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Kenya
Uganda
Participants Gender
Female