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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-lasting effects of bcg vaccination on both heterologous th1/th17 responses and innate trained immunity
Journal of Innate Immunity, Volume 6, No. 2, Year 2014
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Description
We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine production in response to nonrelated pathogens for up to 3 months after vaccination. This phenomenon was named 'trained immunity'. In the present study we assessed whether BCG was able to induce long-lasting effects on both trained immunity and heterologous T helper 1 (Th1) and Th17 immune responses 1 year after vaccination. The production of TNFα and IL-1β to mycobacteria or unrelated pathogens was higher after 2 weeks and 3 months postvaccination, but these effects were less pronounced 1 year after vaccination. However, monocytes recovered 1 year after vaccination had an increased expression of pattern recognition receptors such as CD14, Toll-like receptor 4 (TLR4) and mannose receptor, and this correlated with an increase in proinflammatory cytokine production after stimulation with the TLR4 ligand lipopolysaccharide. The heterologous production of Th1 (IFN-γ) and Th17 (IL-17 and IL-22) immune responses to nonmycobacterial stimulation remained strongly elevated even 1 year after BCG vaccination. In conclusion, BCG induces sustained changes in the immune system associated with a nonspecific response to infections both at the level of innate trained immunity and at the level of heterologous Th1/Th17 responses. © 2013 S. Karger AG, Basel.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3944069/bin/jin-0006-0152-s01.pdf
Authors & Co-Authors
Kleinnijenhuis, Johanneke
Netherlands, Nijmegen
Radboud University Medical Center
Benn, Christine Stabell
Denmark, Copenhagen
Statens Serum Institut
Joosten, Leo A.B.
Netherlands, Nijmegen
Radboud University Medical Center
Xavier, Ramnik J.
United States, Boston
Harvard Medical School
United States, Cambridge
Broad Institute
Aaby, Peter
Denmark, Copenhagen
Statens Serum Institut
van der Meer, Jos W.M.D.
Netherlands, Nijmegen
Radboud University Medical Center
van Crevel, Reinout
Netherlands, Nijmegen
Radboud University Medical Center
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 402
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1159/000355628
ISSN:
1662811X