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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antigenic specificity of lymphocytes isolated from valvular specimens of rheumatic fever patients
Journal of Autoimmunity, Volume 8, No. 4, Year 1995
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Description
T cell lines were established from both valvular specimens and peripheral blood lymphocytes from seven patients with well documented rheumatic heart disease. These cell lines were stimulated with either PHA or streptococcal antigens. Proliferation assays revealed that both valvular and peripheral blood T cell lines reacted to cell wall (CW) and cell membrane (CM) antigens obtained from rheumatic fever associated group A streptococci and not to nephritogenic strains. None of the cell lines reacted to M protein, myosin or other mammalian cytoskeletal proteins. The unique reactivity of rheumatic fever T cell lines only to cellular structures obtained from rheumatogenic strains suggests that these lines react to epitopes specific for antigens obtained from these strains. © 1995 Academic Press Limited.
Authors & Co-Authors
Yoshinaga, Masao
Japan, Kagoshima
Kagoshima University
Figueroa, Fernando
Chile, Santiago
Pontificia Universidad Católica de Chile
Wahid, Rezwanul M.
Japan, Kagoshima
Kagoshima University
Marcus, Richard H.
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Suh, Elsa
United States, New York
Rockefeller University
Zabriskie, John B.
United States, New York
Rockefeller University
Statistics
Citations: 29
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/0896-8411(95)90011-X
ISSN:
08968411
e-ISSN:
10959157
Research Areas
Noncommunicable Diseases