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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Simultaneous spectrofluorimetric determination of amlodipine besylate and valsartan in their combined tablets
Drug Testing and Analysis, Volume 2, No. 10, Year 2010
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Description
Amlodipine, a dihydropyridine calcium channel blocker, and valsartan, an angiotensin II receptor blocker, are co-formulated in a single-dose combination for the treatment of hypertension. The combination is used by patients whose blood pressure is not adequately controlled on either component monotherapy. This work describes a simple, sensitive, and reliable spectrofluorimetric method for the simultaneous determination of the two antihypertensive drugs; amlodipine besylate (AML) and valsartan (VAL) in their combined tablets. The method involved measurement of the native fluorescence at 455 nm (λEx 360 nm) and 378 nm (λEx 245 nm) for AML and VAL, respectively. Analytical performance of the proposed spectrofluorimetric procedure was statistically validated with respect to linearity, ranges, precision, accuracy, selectivity, robustness, detection, and quantification limits. Regression analysis showed good correlation between fluorescence intensity and concentration over the concentration ranges 0.2-3.6 and 0.008-0.080 μg mL-1 for AML and VAL, respectively. The limits of detection were 0.025 and 0.0012 μg mL-1 for AML and VAL, respectively. The proposed method was successfully applied for the assay of the two drugs in their combined pharmaceutical tablets with recoveries not less than 98.85%. No interference was observed from common pharmaceutical additives. The results were favourably compared with those obtained by a reference spectrophotometric method. Copyright © 2010 John Wiley & Sons, Ltd.
Authors & Co-Authors
Shaalan, Rasha Abdel Aziz
Egypt, Alexandria
Faculty of Pharmacy
Belal, Tarek Saied
Egypt, Alexandria
Faculty of Pharmacy
Statistics
Citations: 61
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1002/dta.160
ISSN:
19427603
e-ISSN:
19427611
Research Areas
Noncommunicable Diseases
Study Approach
Quantitative