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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serum Anti-Helicobacter Pylori Lgg Antibodies and Pepsinogens A and C as Serological Markers of Chronic Atrophic Gastritis
Cancer Epidemiology Biomarkers and Prevention, Volume 2, No. 2, Year 1993
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Description
This study was designed to test the sensitivity and specificity of serum anti-Helicobacter pylori IgG antibodies and the ratio of serum pepsinogen A to pepsinogen C (PGA:PGC) in detecting chronic atrophic gastritis (CAG) and intestinal metaplasia. Parallel gastric biopsies and a serum sample were collected from a series of 87 patients aged 20-69 years attending a routine upper endoscopy clinic. The seroprevalence (>10 Mg IgG/ml) of anti-H. pylori antibodies was 42.7%, and of a low PGA:PGC ratio (<1.5) was 17.7%. A positive H. pylori IgG antibody level was more sensitive than the level of PGA:PGC in diagnosing CAG (71.4% and 25.0%, respectively), moderate CAG (86.7% and 26.7%, respectively), and intestinal metaplasia (90.9% and 50.0%, respectively). Anti-H. pylori IgG antibody levels were less specific than PGA:PGC levels in diagnosing CAG (90.9% and 93.9%, respectively), moderate CAG (78.3% and 89.1%, respectively), and intestinal metaplasia (72.6% and 92.2%, respectively). A combination of anti-H. pylori antibodies and a low PGA:PGC ratio for the detection of CAG resulted in a specificity of 100%, but the sensitivity was 21.4%. © 1993, American Association for Cancer Research. All rights reserved.
Authors & Co-Authors
Sitas, F.
United Kingdom, London
Cancer Research uk
Jewell, Derek P.J.
Unknown Affiliation
Newell, Diane G.
United Kingdom, London
Public Health England
Forman, David F.
United Kingdom, London
Cancer Research uk
Statistics
Citations: 35
Authors: 4
Affiliations: 4
Identifiers
ISSN:
10559965
Research Areas
Cancer
Health System And Policy