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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane
FEBS Letters, Volume 586, No. 22, Year 2012
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Description
Crucial to organellogenesis was the development of membrane translocases responsible for delivering proteins to new cellular compartments. This investigation examines the Trichomonas vaginalis hydrogenosome, a mitochondrially derived organelle. We identify an expanded family of putative β-barrel proteins (THOM A-I) comprising nine related sequences. Sub-cellular localisation by immunofluorescence and biochemical fractionation is consistent with THOMs being localised to the hydrogenosomal membrane. Native gel electrophoresis and chemical cross-linking support the ability of THOM proteins to be components of membrane-bound oligomeric protein complexes, consistent with a role in protein translocation. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
Kay, Christopher
United Kingdom, Nottingham
University of Nottingham Medical School
Lawler, Karen
United Kingdom, Nottingham
University of Nottingham Medical School
Self, Tim
United Kingdom, Nottingham
University of Nottingham Medical School
Dyall, Sabrina Devi
Mauritius, Reduit
University of Mauritius
Kerr, Ian Derek
United Kingdom, Nottingham
University of Nottingham Medical School
Statistics
Citations: 5
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.febslet.2012.10.004
ISSN:
00145793
e-ISSN:
18733468