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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Seroprevalence of human T lymphotropic virus antibodies among healthy blood donors at a tertiary centre in Lagos, Nigeria
Pan African Medical Journal, Volume 17, Article 301, Year 2014
Notification
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Description
Introduction: Transmission of human T-lymphotropic viruses (HTLV) occurs from mother to child, by sexual contact and blood transfusion. Presently, in most centres in Nigeria, there is no routine pre-transfusion screening for HTLV. The study aims to determine the prevalence of HTLV-1 and HTLV-2 among healthy blood donors at a tertiary centre in Lagos. Methods: A cross-sectional study was carried out at the blood donor clinic of the Lagos State University Teaching Hospital (LASUTH), Ikeja. About 5mls of venous blood was collected from each subject into a sterile plain bottle after obtaining subject's consent. The serum separated and stored at -200C. Sera were assayed for HTLV by an enzyme-linked immunoassay (ELISA) for the determination of antibodies to HTLV 1 and HTLV -2. Western blot confirmatory testing was done on reactive samples. All donors were also screened for HIV, HBsAg and HCV by rapid kits. Results: The seroprevalence of HTLV -1 by ELISA was 1.0% and 0.5% by Western Blot among blood donors. A total of 210 healthy blood donors were enrolled. Only 2 (1.0%) blood donors were repeatedly reactive with ELISA test. On confirmatory testing with Western Blot, 1 (0.5%) blood donor was positive for HTLV. All the healthy blood donors were negative for HIV, HbsAg and HCV. None of the 210 blood donors had been previously transfused; as such no association could be established between transfusion history and HTLV positivity among the blood donors. Conclusion: The seroprevalence of HTLV in this environment is low among healthy blood donors. © Idris Durojaiye et al.
Authors & Co-Authors
Durojaiye, Idris O.
Nigeria, Lagos
Lagos State University Teaching Hospital
Akinbami, Akinsegun Abduljaleel
Nigeria, Lagos
Lagos State University
Dosunmu, Adedoyin Owolabi
Nigeria, Lagos
Lagos State University
John Olabode, Sarah Oluwatayo
Nigeria
Backcok University
Adediran, Adewumi A.
Nigeria, Lagos
University of Lagos
Uche, Ebele Ifeyinwa
Nigeria, Lagos
Lagos State University
Oshinaike, Olajumoke O.
Nigeria, Lagos
Lagos State University
Odesanya, Majeed Olaniyi
Nigeria, Lagos
Oak Hospitals
Dada, Akinola Olusola
Nigeria, Lagos
Lagos State University
Okunoye, Olaitan
Nigeria, Port Harcourt
University of Port Harcourt
Statistics
Citations: 20
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.11604/pamj.2014.17.301.4075
ISSN:
19378688
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Nigeria