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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Neurodevelopmental Outcomes of Children following in Utero Exposure to Zika in Nicaragua
Clinical Infectious Diseases, Volume 72, No. 5, Year 2021
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Description
Background: Neurodevelopmental outcomes of asymptomatic children exposed to Zika virus (ZIKV) in utero are not well characterized. Methods: We prospectively followed 129 newborns without evidence of congenital Zika syndrome (CZS) up to 24 months of age. Participants were classified as ZIKV exposed or ZIKV unexposed. The Mullen Scales of Early Learning (MSEL) was administered in the participants' homes at 6, 12, 15, 18, 21, and 24 months of age by trained psychologists. Sociodemographic data, medical history, and infant anthropometry at birth were collected at each home visit. Our primary outcome was the Mullen Early Learning Composite Score (ECL) at 24 months of age between our 2 exposure groups. Secondary outcomes were differences in MSEL subscales over time and at 24 months. Results: Of 129 infants in whom exposure status could be ascertained, 32 (24.8%) met criteria for in utero ZIKV exposure and 97 (75.2%) did not. There were no differences in maternal age, maternal educational attainment, birthweight, or gestational age at birth between the 2 exposure groups. The adjusted means and standard errors (SEs) for the ELC score between the ZIKV-exposed children compared to ZIKV-unexposed children were 91.4 (SE, 3.1) vs 96.8 (SE, 2.4) at 12 months and 93.3 (SE, 2.9) vs 95.9 (SE, 2.3) at 24 months. In a longitudinal mixed model, infants born to mothers with an incident ZIKV infection (P =. 01) and low-birthweight infants (<2500 g) (P =. 006) had lower composite ECL scores. Conclusions: In this prospective cohort of children without CZS, children with in utero ZIKV exposure had lower neurocognitive scores at 24 months. © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC7935385/bin/ciaa1833_suppl_supplementary_material.docx
Authors & Co-Authors
Stringer, Elizabeth Mc Phillips
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Blette, Bryan
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Boivin, Michael Joseph
United States, East Lansing
Michigan State University
Stringer, Jeffrey S.A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Familiar-López, Itziar M.
United States, East Lansing
Michigan State University
Collins, Matthew H.
United States, Atlanta
Emory University
Bowman, Natalie Mc Carter
United States, Chapel Hill
The University of North Carolina at Chapel Hill
de Silva, Aravinda Manu D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Westreich, Daniel J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hudgens, Michael G.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Becker-Dreps, Sylvia I.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 16
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1093/cid/ciaa1833
ISSN:
10584838
Research Areas
Infectious Diseases
Maternal And Child Health
Mental Health
Study Design
Cohort Study