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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antileishmanial and antibacterial activity of a new pyrazole derivative designated 4-[2-(1-(ethylamino)-2-methyl-propyl)phenyl]-3-(4-methyphenyl)-1- phenylpyrazole
Archiv der Pharmazie, Volume 339, No. 6, Year 2006
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Description
Here, we report for the first time the synthesis and the antileishmanial activity of a new pyrazole derivative, namely 4-[2-(1-(ethylamino)-2- methylpropyl)phenyl]-3-(4-methyphenyl)-1-phenylpyrazole). Micromolar concentrations of this compound were found to inhibit the in vitro multiplication of Leishmania tropica, Leishmania major, and Leishmania infantum, three species causing different forms of leishmaniasis. Furthermore, the 50% inhibitory concentration (IC50) values for the compound are only slightly higher than those of amphotericin B, one of the most active antileishmanial agents used as a satisfactory substitute in cases not responding to pentostam. The IC50 values after 48 h for L. tropica, L. major, and L. infantum promastigote growth were 0.48 μg/, mL, 0.63 μg/mL and 0.40 μg/mL, respectively for the compound, while they were 0.23 μg/mL, 0.29 μg/mL and 0.24 μg/mL, respectively for amphotericin B. We also tested this compound for its antibacterial activity against several bacteria. The strongest antibacterial activity was observed against Entrococcus feacalis and Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 60 μg/mL. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
Authors & Co-Authors
Dardari, Zainaba
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Lemrani, Meryem
Morocco, Casablanca
Institut Pasteur du Maroc
Sebban, Abdelfatah
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Bahloul, Abdelmejid
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Hassar, Mohammed
Morocco, Casablanca
Institut Pasteur du Maroc
Kitane, Saïd
Morocco, Agdal Rabat
Ecole Nationale de L'industrie Minérale
Berrada, Mohammed
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Boudouma, Mohammed
Morocco, Casablanca
Faculté Des Sciences Ben M’sick
Statistics
Citations: 30
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/ardp.200500266
ISSN:
03656233
e-ISSN:
15214184