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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Immunogenicity and tolerability after two doses of non-adjuvanted, whole-virion pandemic influenza a (H1N1) vaccine in HIV-infected individuals
PLoS ONE, Volume 7, No. 5, Article e36773, Year 2012
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Description
Background: During the influenza pandemic of 2009/10, the whole-virion, Vero-cell-derived, inactivated, pandemic influenza A (H1N1) vaccine Celvapan® (Baxter) was used in Austria. Celvapan® is adjuvant-free and was the only such vaccine at that time in Europe. The objective of this observational, non-interventional, prospective single-center study was to evaluate the immunogenicity and tolerability of two intramuscular doses of this novel vaccine in HIV-positive individuals. Methods and Findings: A standard hemagglutination inhibition (HAI) assay was used for evaluation of the seroconversion rate and seroprotection against the pandemic H1N1 strain. In addition, H1N1-specific IgG antibodies were measured using a recently developed ELISA and compared with the HAI results. Tolerability of vaccination was evaluated up to one month after the second dose. A total of 79 HIV-infected adults with an indication for H1N1 vaccination were evaluated. At baseline, 55 of the 79 participants had an HAI titer ≥1:40 and two patients showed a positive IgG ELISA. The seroconversion rate was 31% after the first vaccination, increasing to 41% after the second; the corresponding seroprotection rates were 92% and 83% respectively. ELISA IgG levels were positive in 25% after the first vaccination and in 37% after the second. Among the participants with baseline HAI titers <1:40, 63% seroconverted. Young age was clearly associated with lower HAI titers at baseline and with higher seroconversion rates, whereas none of the seven patients >60 years of age had a baseline HAI titer <1:40 or seroconverted after vaccination. The vaccine was well tolerated. Conclusion: The non-adjuvanted pandemic influenza A (H1N1) vaccine was well tolerated and induced a measurable immune response in a sample of HIV-infected individuals. © 2012 Lagler et al.
Authors & Co-Authors
Lagler, Heimo
Austria, Vienna
Medizinische Universität Wien
Grabmeier-Pfistershammer, Katharina
Austria, Vienna
Medizinische Universität Wien
Ramharter, Michael
Austria, Vienna
Medizinische Universität Wien
Germany, Tubingen
Eberhard Karls Universität Tübingen
Redlberger-Fritz, Monika
Austria, Vienna
Medizinische Universität Wien
Popow-Kraupp, Therese
Austria, Vienna
Medizinische Universität Wien
Rieger, Armin C.
Austria, Vienna
Medizinische Universität Wien
Burgmann, H.
Austria, Vienna
Medizinische Universität Wien
Statistics
Citations: 15
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0036773
ISSN:
19326203
Research Areas
Infectious Diseases
Study Design
Cohort Study