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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Misclassification of drug failure in plasmodium falciparum clinical trials in southeast asia
Journal of Infectious Diseases, Volume 200, No. 4, Year 2009
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Description
Most trials of antimalarials occur in areas in which reinfections are possible. For Plasmodium falciparum, reinfections are distinguished from recrudescences by polymerase chain reaction analysis of 3 polymorphic genes. However, the validity of this approach has never been rigorously tested. We tested for misclassification in 6 patients from clinical trials in Thailand and Cambodia who were classified as being reinfected by the standard polymerase chain reaction protocol. Using heteroduplex tracking assays and direct DNA sequencing, we found that 5 (83%) of 6 patients were misclassified. Misclassification in this manner overestimates the efficacy of antimalarials and delays the recognition of decreasing therapeutic efficacy, thus delaying potential changes in policy. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Juliano, Jonathan J.
United States, Chapel Hill
Unc School of Medicine
Ariey, Frédéric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Sem, Rithy
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Tangpukdee, Noppadon
Thailand, Nakhon Pathom
Mahidol University
Krudsood, Srivicha
Thailand, Nakhon Pathom
Mahidol University
Looareesuwan, Sornchai
Thailand, Nakhon Pathom
Mahidol University
Rogers, William Oscar
Unknown Affiliation
Wongsrichanalai, Chansuda
Unknown Affiliation
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 21
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1086/600892
ISSN:
00221899
Research Areas
Genetics And Genomics
Health System And Policy