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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Beyond Chloroquine: Implications of Drug Resistance for Evaluating Malaria Therapy Efficacy and Treatment Policy in Africa
Journal of Infectious Diseases, Volume 167, No. 4, Year 1993
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Description
Emphasis on retaining chloroquine as the first-line therapy for Plasmodium falciparum infections in most of sub-Saharan Africa for as long as it remains effective has resulted in widespread reliance on chloroquine in areas where it can have little effect on P. falciparum parasitemia. To address this issue, clinical, parasitologic, and hematologic responses to chloroquine or pyrimethamine/sulfadoxine treatment were assessed among very young children in Malawi (n = 153) and Kenya (n = 73). The median time to resumption of clinical symptoms in chloroquine-treated children was 13.5 days in Malawi and 9.5 days in Kenya. Children treated with pyrimethamine/sulfadoxine maintained clinical improvement and had greater increases in their hemoglobin concentration during the follow-up period than did children treated with chloroquine. Treatment with chloroquine failed to produce either a durable clinical improvement or optimal hematologic recovery. Consequently, chloroquine can no longer be considered adequately effective therapy of clinical P. falciparum malaria in very young children in these areas of Africa. © 1993 by The University of Chicago.
Authors & Co-Authors
Bloland, Peter Brian
United States, Atlanta
National Center for Infectious Diseases
Malawi, Lilongwe
Ministry of Health Malawai
United States, Nairobi
Kenya Medical Research Institute
Lackritz, Eve M.
United States, Atlanta
National Center for Infectious Diseases
Malawi, Lilongwe
Ministry of Health Malawai
United States, Nairobi
Kenya Medical Research Institute
Kazembe, Peter Nicholas
United States, Atlanta
National Center for Infectious Diseases
Malawi, Lilongwe
Ministry of Health Malawai
United States, Nairobi
Kenya Medical Research Institute
Were, Joab Ben O.
United States, Atlanta
National Center for Infectious Diseases
Malawi, Lilongwe
Ministry of Health Malawai
United States, Nairobi
Kenya Medical Research Institute
Steketee, Richard W.
United States, Atlanta
National Center for Infectious Diseases
Malawi, Lilongwe
Ministry of Health Malawai
United States, Nairobi
Kenya Medical Research Institute
Campbell, Carlos C.(Kent)
United States, Atlanta
National Center for Infectious Diseases
Malawi, Lilongwe
Ministry of Health Malawai
United States, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 319
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/167.4.932
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya
Malawi