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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Recombination networks as genetic markers in a human variation study of the Old World
Human Genetics, Volume 131, No. 4, Year 2012
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Description
We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,288 individuals (mostly males). We use a novel analysis employing subARG network construction with recombining chromosomal segments. Here, a subARG is constructed independently for each of five gene-free regions across the X chromosome, and the results are aggregated across them. For PCA, MDS and ancestry inference with STRUCTURE, the subARG is processed to obtain feature vectors of samples and pairwise distances between samples. The observed population structure, estimated from the five short X chromosomal segments, supports genome-wide frequency-based analyses: African populations show higher genetic diversity, and the general trend of shared variation is seen across the globe from Africa through Middle East, Europe, Central Asia, Southeast Asia, and East Asia in broad patterns. The recombinational analysis was also compared with established methods based on SNPs and haplotypes. For haplotypes, we also employed a fixed-length approach based on information-content optimization. Our recombinational analysis suggested a southern migration route out of Africa, and it also supports a single, rapid human expansion from Africa to East Asia through South Asia. © Springer-Verlag 2011.
Authors & Co-Authors
Javed, Asif
United States, Yorktown Heights
Ibm Thomas J. Watson Research Center
Melé, Marta
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Pybus, Marc
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Zalloua, Pierre A.
Lebanon, Beirut
Lebanese American University
Haber, Marc E.
Lebanon, Beirut
Lebanese American University
Comas, D.
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Balanovsky, Oleg P.
Russian Federation, Moscow
Research Centre for Medical Genetics
Russian Federation, Moscow
Vavilov Institute of General Genetics, Russian Academy of Sciences
Balanovska, Elena V.
Russian Federation, Moscow
Research Centre for Medical Genetics
Jin, Li
China, Shanghai
Fudan University
Yang, Yajun
China, Shanghai
Fudan University
Kumar, Ganesh Prasad Arun
India, Madurai
Madurai Kamaraj University
Pitchappan, Ramasamy M.
India, Madurai
Madurai Kamaraj University
India, Kelambakkam
Chettinad Academy of Research and Education
Bertranpetit, Jaume
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Calafell, Francesc
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Parida, Laxmi P.
United States, Yorktown Heights
Ibm Thomas J. Watson Research Center
Statistics
Citations: 16
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1007/s00439-011-1104-8
ISSN:
03406717
e-ISSN:
14321203
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study