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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence of factor V Leiden in south Tunisian blood donors
Journal of Thrombosis and Thrombolysis, Volume 32, No. 1, Year 2011
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Description
Venous thrombosis (VT) is a common disease with multifactorial pathogenesis. Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis. The prevalence of FVL varies according to geography and ethnicity. Hence, in several countries there is a difference in the frequency of this mutation between the southern, central and north. In Tunisia, no data is available about prevalence of FVL mutation by geographical origin. For this reason, we sought the prevalence of FVL mutation in blood donor of south Tunisia population. FVL has been detected by APCR-test and confirmed by PCR-RFLP and sequencing. Two hundred fifty blood donors, different in age and sex were included in this study to determine the prevalence of FVL in blood donors. FVL mutation was found in 13.6% of the studied population. Thirty-one were heterozygous and three persons were homozygous with a rate of 12.4 and 1.2%, respectively. In conclusion, FVL mutation is very common in south Tunisian population. © Springer Science+Business Media, LLC 2011.
Authors & Co-Authors
Maalej, Lobna
Tunisia, Sfax
Faculty of Medicine of Sfax
HadjKacem, Basma
Tunisia, Sfax
Centre de Biotechnologie de Sfax
ikram, Ben amor
Tunisia, Sfax
Faculty of Medicine of Sfax
Smaoui, Mariem
Tunisia, Sfax
Faculty of Medicine of Sfax
Gargouri, Ali Faouzi
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Gargouri, Jalel
Tunisia, Sfax
Faculty of Medicine of Sfax
Statistics
Citations: 9
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1007/s11239-011-0582-9
ISSN:
09295305
e-ISSN:
1573742X
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Tunisia