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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens
Journal of Infectious Diseases, Volume 193, No. 3, Year 2006
Notification
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Description
Most cases of latent tuberculosis infection (LTBI) do not cause symptoms during the lifetime of the infected person. Longitudinal analysis of the immune response of healthy Mycobacterium tuberculosis-infected people might, therefore, give insight into the basis of protective immunity. In a longitudinal study, we documented the effect that treatment had on the T cell response to M. tuberculosis antigens in 33 healthy people with LTBI. Preventive treatment of LTBI resulted in a 1.8-fold average increase in the numbers of interferon (IFN)-γ-producing T cells within 26 ± 4 days (P = .006), followed by a decrease by the end of the treatment period (82 ± 6 days; P = .004). There was no significant overall change in the T cell response to any antigen in a control group (n = 8) of patients who elected radiological follow-up. Using live M. tuberculosis strain H37Rv as a stimulant in an enzyme-linked immunospot assay in sensitized individuals, we showed that isoniazid, but not rifampin, led to an increase in the number of IFN-γ-producing cells. These results suggest that the integrity of the bacterial cell wall is important for M. tuberculosis in avoiding immune recognition by T cells and favor a dynamic model of LTBI. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Andrea Wilkinson, Katalin Andrea
United Kingdom, London
Imperial College London
South Africa, Cape Town
Faculty of Health Sciences
Kon, Onn Min
United Kingdom, London
St Mary's Hospital
Newton, Sandra M.
United Kingdom, London
Imperial College London
Meintjes, Graeme Ayton
United Kingdom, London
Imperial College London
South Africa, Cape Town
Faculty of Health Sciences
Davidson, Robert N.
United Kingdom, Harrow
Northwick Park Hospital
Pasvol, Geoffrey
United Kingdom, London
Imperial College London
United Kingdom, Harrow
Northwick Park Hospital
Wilkinson, Robert J.
United Kingdom, London
Imperial College London
United Kingdom, Harrow
Northwick Park Hospital
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 126
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1086/499311
ISSN:
00221899
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative