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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The protozoan parasite, Theileria annulata, induces a distinct acute phase protein response in cattle that is associated with pathology
International Journal for Parasitology, Volume 33, No. 12, Year 2003
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Description
Acute phase proteins (APP) are synthesised in the liver in response to the systemic presence of high levels of pro-inflammatory cytokines. Bacteria are considered to be strong inducers of APP whereas viruses are weak or non-inducers of APP. Very few reports have been published on APP induction by parasites. Here, we report that the tick-borne protozoan parasite of cattle, Theileria annulata, induced an atypical acute phase response in cattle. Following experimental infection, serum amyloid A (SAA) appeared first, followed by a rise in α1 acid glycoprotein (α 1AGP) in all animals, whereas haptoglobin, which is a major APP in cattle, only appeared in some of the animals, and generally at a low level. All three APP only became elevated around or after the appearance of schizonts in draining lymph nodes and after the first observed temperature rise. Increased α1AGP levels coincided with the appearance of piroplasms. The production of SAA and α1AGP correlated strongly with each other, and also with some clinical measures of disease severity including the time to fever, development of leucopaenia, parasitaemia and mortality. These results are consistent with the hypothesis that T. annulata causes severe pathology in susceptible cattle by inducing high levels of pro-inflammatory cytokines. © 2003 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Glass, Elizabeth Janet
United Kingdom, Midlothian
University of Edinburgh, Roslin Institute
Craigmile, Susan C.L.
United Kingdom, Midlothian
University of Edinburgh, Roslin Institute
Preston, Patricia M.
United Kingdom, Edinburgh
The University of Edinburgh
Kirvar, Erol
United Kingdom, Edinburgh
The University of Edinburgh
Wilkie, Gwen M.
United Kingdom, Edinburgh
The University of Edinburgh
Eckersall, Peter David
United Kingdom, Glasgow
University of Glasgow
Hall, Roger F.
United Kingdom, York
University of York
Brown, C. G.Duncan
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 62
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/S0020-7519(03)00166-8
ISSN:
00207519