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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients
Journal of Translational Medicine, Volume 10, No. 1, Article 248, Year 2012
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Description
Background: The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML).Methods: JCV-specific CD8+ T lymphocytes were evaluated by flow cytometry over a 24-month period in 24 natalizumab-treated MS patients in whom JCV DNA was or was not detected in blood using quantitative real-time polymerase chain reaction; all these cases were asymptomatic.Results: Perforin- and grazymes-containing VP-1-specific CD8+ T lymphocytes were reduced whereas CD107a-expressing cells were increased in JCV positive patients, suggesting an active degranulation of these cells; naïve CD8+ T lymphocytes were also decreased whereas memory cells were increased in patients in whom JCV reactivation was observed.Conclusion: The presence of a CD8+ T lymphocyte-mediated effector immune response offers a greater insight into reactivation of JCV and its clinical sequelae, and may help the monitoring of patients on natalizumab therapy. © 2012 Mancuso et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Saresella, Marina
Italy, Milan
Fondazione Don Carlo Gnocchi
Ricci, Cristian
Italy, Milan
Fondazione Don Carlo Gnocchi
Clerici, Mario S.
Italy, Milan
Fondazione Don Carlo Gnocchi
Italy, Milan
Università Degli Studi Di Milano
Statistics
Citations: 18
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1186/1479-5876-10-248
ISSN:
14795876
Research Areas
Genetics And Genomics
Study Approach
Quantitative