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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.
Phytochemistry, Volume 102, Year 2014
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Description
Neoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the isolation of nine cycloartane triterpenes (1-9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9,10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-O-acetyl-26- deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13). The chemical structures of the compounds were established mainly through a combination of spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven out of 13 compounds exhibited good antiplasmodial activity with IC50 of ≤5 μg/ml with two compounds exhibiting low cytotoxicity and five compounds having significant cytotoxicity. © 2014 Published by Elsevier Ltd.
Authors & Co-Authors
Namukobe, Jane
Uganda, Kampala
Makerere University
Kiremire, Bernard Turyagenda
Uganda, Kampala
Makerere University
Byamukama, Robert
Uganda, Kampala
Makerere University
Kasenene, John Massan K.
Uganda, Fort Portal
Mountains of the Moon University
Dumontet, Vincent
France, Paris
Cnrs Centre National de la Recherche Scientifique
Guéritte, Françoise
France, Paris
Cnrs Centre National de la Recherche Scientifique
Krief, Sabrina
France, Paris
Museum National D'histoire Naturelle
Uganda, Fort Portal
Sebitoli Chimpanzee Project
Florent, Isabelle
France, Paris
Cnrs Centre National de la Recherche Scientifique
Kabasa, John David
Uganda, Kampala
College of Veterinary Medicine
Statistics
Citations: 18
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/j.phytochem.2014.02.005
ISSN:
00319422
Research Areas
Cancer
Infectious Diseases
Study Locations
Uganda