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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
International variations in bronchial responsiveness in children: Findings from ISAAC phase two
Pediatric Pulmonology, Volume 45, No. 8, Year 2010
Notification
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Description
Rationale: Bronchial responsiveness is an objectively measurable trait related to asthma. Its prevalence and association with asthma symptoms among children in many countries are unknown. Objectives: To investigate international variations in bronchial responsiveness (BR) and their associations with asthma symptoms and atopic sensitization. Methods: Bronchial challenge tests were conducted in 6,826 schoolchildren (aged 8-12 years) in 16 countries using hypertonic (4.5%) saline. FEV1 was measured at baseline and after inhalation for 0.5, 1, 2, 4, and 8 min. BR was analyzed both as a dichotomous (bronchial hyperreactivity, BHR, at least 15% decline in FEV1) and as a continuous variable (time - response slope,BRslope, individual decline in FEV1 per log(min)). Results: Prevalence of wheeze last year ranged from 4.4% in Tirana (Albania) to 21.9% in Hawkes Bay (New Zealand) and of BHR from 2.1% in Tirana to 48% in Mumbai (India). The geometric mean BR slope varied between 3.4%/log(min) in Tirana and 12.8%/log(min) in Mumbai and Rome (Italy). At the individual level, BHR was positively associated with wheeze during the past 12 months both in affluent countries (OR=3.6; 95% CI: 2.7-5.0) and non-affluent countries (OR=3.0; 1.6-5.5). This association was more pronounced in atopic children. There was a correlation (r=0.64, P=0.002) between center-specific mean BR slope and wheeze prevalence in atopic, but not in non-atopic children. Conclusions: BR to saline in children varied considerably between countries. High rates of BR were not confined to affluent countries nor to centers with high prevalences of asthma symptoms. The association between wheeze and BHRat the individual level differed across centers and this heterogeneity can be largely explained by effect modification by atopy. © 2010 Wiley-Liss, Inc.
Authors & Co-Authors
Büchele, Gisela
Germany, Ulm
Universität Ulm
Genuneit, Jon
Germany, Ulm
Universität Ulm
Weinmayr, Gudrun
Germany, Ulm
Universität Ulm
Bjõrkstén, Bengt
Sweden, Stockholm
Karolinska Institutet
Gehring, Ulrike
Netherlands, Utrecht
Institute for Risk Assessment Sciences
von Mutius, Erika R.M.
Germany, Munich
Ludwig-maximilians-universität München
Priftanji, Alfred V.
Albania, Tirana
University Hospital Centre Tirana
Stein, Renato Tetelbom
Brazil, Campinas
Pontificia Universidade Catolica de Campinas
Addo-Yobo, Emmanuel O.D.
Ghana, Kumasi
Komfo Anokye Teaching Hospital
Priftis, Kostas
Greece, Athens
Penteli General Hospital for Children
Shah, Jayant R.
India, Mumbai
Jaslok Hospital and Research Centre
Forastiére, Francesco
Italy, Rome
Rome e Health Authority
Švabe, Vija
Latvia, Riga
Childrens Hospital
Crane, Julian
New Zealand, Dunedin
Otago Medical School
Nystad, Wenche
Norway, Oslo
Folkehelseinstituttet
García-Marcos, Luis
Spain, Murcia
Hospital Clínico Universitario Virgen de la Arrixaca
Saraçlar, Yildiz
Turkey, Ankara
Hacettepe Üniversitesi
El-Sharif, Nuha A.
Palestine, Abu Dis
Al-quds University
Strachan, David Peter
United Kingdom, London
St George's Hospital
Weiland, Stephan Karl
Germany, Ulm
Universität Ulm
Dentler, C.
Germany, Ulm
Universität Ulm
Kleiner, A.
Germany, Ulm
Universität Ulm
Rzehak, P.
Germany, Ulm
Universität Ulm
Shkurti, A.
Unknown Affiliation
Simenati, J.
Unknown Affiliation
Grabocka, E.
Unknown Affiliation
Shyti, K.
Unknown Affiliation
Agolli, S.
Unknown Affiliation
Gurakuqi, A.
Unknown Affiliation
Urrutia de Pereira, M.
Unknown Affiliation
Jones, M. H.
Unknown Affiliation
Pitrez, Paulo Márcio Condessa
Unknown Affiliation
Cooper, Philip John
Unknown Affiliation
Chico, Martha E.
Unknown Affiliation
Chen, Yuzhi
Unknown Affiliation
Zhong, Nanshan
Unknown Affiliation
Lai, Christopher K.W.
Unknown Affiliation
Wong, Gary Wing Kin
Unknown Affiliation
Riikjärv, Mall Anne
Unknown Affiliation
Annus, T.
Unknown Affiliation
Annesi-Maesano, Isabella I.
Unknown Affiliation
Gotua, Maia A.
Unknown Affiliation
Rukhadze, M.
Unknown Affiliation
Abramidze, T.
Unknown Affiliation
Kvachadze, I.
Unknown Affiliation
Karsanidze, L.
Unknown Affiliation
Kiladze, M.
Unknown Affiliation
Dolidze, N.
Unknown Affiliation
Leupold, W.
Unknown Affiliation
Keil, Ulrich
Unknown Affiliation
Arthur, Paul
Unknown Affiliation
Gratziou, Christina G.
Unknown Affiliation
Papadopoulou, A.
Unknown Affiliation
Katsardis, C.
Unknown Affiliation
Tsanakas, John N.
Unknown Affiliation
Hatziagorou, E.
Unknown Affiliation
Kirvassilis, F.
Unknown Affiliation
Clausen, M.
Unknown Affiliation
Mathur, R. S.
Unknown Affiliation
Khubchandani, Raju P.
Unknown Affiliation
Mantri, S. N.
Unknown Affiliation
Di Domenicantonio, R.
Unknown Affiliation
De Sario, Manuela
Unknown Affiliation
Sammarro, S.
Unknown Affiliation
Pistelli, R.
Unknown Affiliation
Serra, M. G.
Unknown Affiliation
Corbo, G.
Unknown Affiliation
Perucci, C. A.
Unknown Affiliation
Sebre, D.
Unknown Affiliation
Casno, G.
Unknown Affiliation
Novikova, I.
Unknown Affiliation
Bagrade, L.
Unknown Affiliation
Brunekreef, Bert A.
Unknown Affiliation
Schram, D.
Unknown Affiliation
Doekes, G.
Unknown Affiliation
Jansen-Van Vliet, P. H.N.
Unknown Affiliation
Janssen, Nicole A.H.
Unknown Affiliation
Aarts, F. J.H.
Unknown Affiliation
De Meer, G.
Unknown Affiliation
Wickens, K.
Unknown Affiliation
Barry, David M.J.
Unknown Affiliation
Bolle, R.
Unknown Affiliation
Lund, Eiliv
Unknown Affiliation
Batllés-Garrido, José
Unknown Affiliation
Rubi Ruiz, T.
Unknown Affiliation
Perales, A. Bonillo
Unknown Affiliation
Gonzalez Jiménez, Y.
Unknown Affiliation
Aguirre Rodriguez, J.
Unknown Affiliation
Momblan de Cabo, J.
Unknown Affiliation
Losilla Maldonado, A.
Unknown Affiliation
Daza Torres, M.
Unknown Affiliation
Martinez-Torres, Antonela
Unknown Affiliation
Guillén Pérez, J. J.
Unknown Affiliation
Piñana López, A.
Unknown Affiliation
Castejon Robles, S.
Unknown Affiliation
García-Hernández, Gloria
Unknown Affiliation
Martinez Gimeno, A.
Unknown Affiliation
Moro Rodríguez, A. L.
Unknown Affiliation
Luna-Paredes, Carmen
Unknown Affiliation
Gonzalez Gil, I.
Unknown Affiliation
Statistics
Citations: 100
Authors: 100
Affiliations: 17
Identifiers
Doi:
10.1002/ppul.21259
ISSN:
87556863
e-ISSN:
10990496
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study