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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa
Antiviral Research, Volume 83, No. 1, Year 2009
Notification
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Description
The neuraminidase inhibitors (NAIs) are an effective class of antiviral drugs for the treatment of influenza A and B infections. Until recently, only a low prevalence of NAI resistance (<1%) had been detected in circulating viruses. However, surveillance in Europe in late 2007 revealed significant numbers of A(H1N1) influenza strains with a H274Y neuraminidase mutation that were highly resistant to the NAI oseltamivir. We examined 264 A(H1N1) viruses collected in 2008 from South Africa, Oceania and SE Asia for their susceptibility to NAIs oseltamivir, zanamivir and peramivir in a fluorescence-based neuraminidase inhibition assay. Viruses with reduced oseltamivir susceptibility were further analysed by pyrosequencing assay. The frequency of the oseltamivir-resistant H274Y mutant increased significantly after May 2008, resulting in an overall proportion of 64% (168/264) resistance among A(H1N1) strains, although this subtype represented only 11.6% of all isolates received during 2008. H274Y mutant viruses demonstrated on average a 1466-fold reduction in oseltamivir susceptibility and 527-fold reduction in peramivir sensitivity compared to wild-type A(H1N1) viruses. The mutation had no impact on zanamivir susceptibility. Ongoing surveillance is essential to monitor how these strains may spread or persist in the future and to evaluate the effectiveness of treatments against them. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Hurt, Aeron C.
Australia, Canberra
World Health Organization, Australia
Australia, Ballarat
Federation University Australia
Ernest, Joanne
Australia, Canberra
World Health Organization, Australia
Deng, Yi Mo
Australia, Canberra
World Health Organization, Australia
Iannello, Pina
Australia, Canberra
World Health Organization, Australia
Besselaar, Terry G.
South Africa, Johannesburg
National Institute for Communicable Diseases
Birch, Chris J.
Australia
Victorian Infectious Diseases Reference Laboratory
Buchy, Philippe
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Chittaganpitch, Malinee
United States, Bethesda
National Institutes of Health Nih
Chiu, Shu Chun
Taiwan, Hualien
Centers for Disease Control
Dwyer, Dominic Edmund
Australia, Sydney
Westmead Hospital
Guigon, Aurélie
New Caledonia
Pasteur Institute
Harrower, Bruce
Australia, Brisbane
Queensland Health
Kei, Ip Peng
Macao, Bureau
Public Health Laboratory
Kok, Tuckweng
Australia, Adelaide
Institute of Medical and Veterinary Science Australia
Lin, Cui
Singapore, Singapore City
Ministry of Health, Government of Singapore
McPhie, Ken
Australia, Sydney
Westmead Hospital
Mohd, Apandi
Malaysia, Kuala Lumpur
Pusat Penyelidikan Perubatan Herbal
Olveda, Remigio M.
Philippines, Manila
Research Institute of Tropical Medicine
Panayotou, Tony
Australia, Clayton
Monash Health
Rawlinson, William D.
Australia, Sydney
Prince of Wales Hospital
Scott, Lesley
Australia, Darwin
Centre for Disease Control
Smith, David W.
Australia, Perth
Pathwest Laboratory Medicine wa
D'Souza, Holly
New Zealand, Auckland
Auckland City Hospital
Komadina, Naomi
Australia, Canberra
World Health Organization, Australia
Shaw, Robert
Australia, Canberra
World Health Organization, Australia
Kelso, Anne
Australia, Canberra
World Health Organization, Australia
Barr, Ian George
Australia, Canberra
World Health Organization, Australia
Australia, Ballarat
Federation University Australia
Statistics
Citations: 271
Authors: 27
Affiliations: 20
Identifiers
Doi:
10.1016/j.antiviral.2009.03.003
ISSN:
01663542
e-ISSN:
18729096
Research Areas
Cancer
Study Design
Cross Sectional Study
Study Locations
South Africa