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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human papillomavirus prevalence and type distribution in 3603 HIV-positive and HIV-Negative Women in the General Population of Tanzania: The PROTECT study
Sexually Transmitted Diseases, Volume 39, No. 3, Year 2012
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Description
OBJECTIVE:: The aim of the Prevention of Cervical Cancer in Tanzania (PROTECT) study is to assess the prevalence of oncogenic human papillomavirus (HPV) and to determine the type distribution among women in the general population according to human immunodeficiency virus (HIV) status, in preparation for a potential HPV immunization program. METHODS:: We included 3603 women from the general population in urban and rural areas of Tanzania. All women underwent a gynecological examination where a Pap smear was obtained and cervical cells were collected to assess the presence of high-risk (HR) HPV DNA by hybrid capture 2 test. Genotyping was performed by the LiPaExtra method. These women were also tested for HIV. RESULTS:: The prevalence of HR HPV types was 20.1%, ranging from 14.8% in women with normal cytology to 94.2% in women with high grade squamous intraepithelial lesion (HSIL) or worse (100% in 5 cancers). In women with normal cytology or low-grade lesions, the most common type was HPV52 (3.2%), followed by HPV16 (2.1%). In contrast, HPV16 was the dominating type in HSIL or worse (32.8%). No cancers contained HPV52. The HR HPV prevalence was higher in HIV-positive women (46.7%) than in HIV-negative women (17.2%). No specific HR HPV types were significantly more common in HIV-positive women. CONCLUSION:: The HPV type distribution is similar in HIV-positive and HIV-negative women. These results suggest that the HPV vaccines that are currently available could protect women from HPV infection independently of their HIV status. © 2012 American Sexually Transmitted Diseases Association All rights reserved.
Authors & Co-Authors
Dartell, Myassa
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Institute of Cancer Epidemiology - Denmark
Rasch, Vibeke
Denmark, Copenhagen
Københavns Universitet
Denmark, Odense
Odense Universitetshospital
Kahesa, Crispin
Tanzania, Dar es Salaam
Division of Cancer Prevention
Mwaiselage, Julius David
Tanzania, Dar es Salaam
Division of Cancer Prevention
Ngoma, Twalib Athumani
Tanzania, Dar es Salaam
Division of Cancer Prevention
Junge, Jette
Denmark, Hvidovre
Hvidovre Hospital
Gernow, Anne
Denmark, Hvidovre
Hvidovre Hospital
Funch Ejlersen, Sussie
Denmark, Hvidovre
Hvidovre Hospital
Munk, Christian
Denmark, Copenhagen
Institute of Cancer Epidemiology - Denmark
Iftner, Thomas
Unknown Affiliation
Kjaer, Susanne Krûger
Denmark, Copenhagen
Institute of Cancer Epidemiology - Denmark
Denmark, Copenhagen
Københavns Universitet
Statistics
Citations: 73
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1097/OLQ.0b013e31823b50ad
ISSN:
01485717
e-ISSN:
15374521
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Tanzania
Participants Gender
Female