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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis c virus genotype 4 infection in an egyptian cohort
Journal of Infectious Diseases, Volume 204, No. 9, Year 2011
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Description
Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P =. 0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa. © 2011 The Author.
Authors & Co-Authors
Kurbanov, F.
United States, Baltimore
Johns Hopkins University
Abdel-Hamid, Mohamed A.
Egypt, Minya
Faculty of Medicine
Latanich, Rachel
United States, Baltimore
Johns Hopkins University
Astemborski, Jacqueline A.
United States, Baltimore
Johns Hopkins University
Mohamed, Mostafa K.
Egypt, Cairo
Ain Shams University
NNH Mikhail, Nabiel N.H.
Egypt, Asyut
Assiut University
El-Daly, Maï Mohamed
Egypt, Cairo
National Liver Institute
A El-Kafrawy, Sherif Aly
Egypt, Cairo
National Liver Institute
Thomas, David L.
United States, Baltimore
Johns Hopkins University
Thio, Chloe Lynne
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 46
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/jir536
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
Multi-countries