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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: A meta-analysis of VBM studies
BMC Psychiatry, Volume 13, Article 110, Year 2013
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Description
Background: Structural imaging studies demonstrate brain tissue abnormalities in eating disorders, yet a quantitative analysis has not been done.Methods: In global and regional meta-analyses of 9 voxel-based morphometry (VBM) studies, with a total of 228 eating disorder participants (currently ill with anorexia nervosa), and 240 age-matched healthy controls, we compare brain volumes using global and regional analyses.Results: Anorexia nervosa (AN) patients have global reductions in gray (effect size = -0.66) and white matter (effect size = -0.74) and increased cerebrospinal fluid (effect size = 0.98) and have regional decreases in left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate, and no significant increases. No significant difference in hemispheric lateralization was found.Conclusions: Global and regional meta-analyses suggest that excessive restrained eating as found in those with anorexia nervosa coincides with structural brain changes analogous to clinical symptoms. © 2013 Titova et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Titova, Olga E.
Sweden, Uppsala
Uppsala Universitet
Schiöth, Helgi Birgir
Sweden, Uppsala
Uppsala Universitet
Brooks, Samantha Jane
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 146
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1186/1471-244X-13-110
ISSN:
1471244X
Study Approach
Quantitative
Systematic review