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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Variable host-pathogen compatibility in Mycobacterium tuberculosis
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 8, Year 2006
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Description
Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the global population structure of M. tuberculosis is defined by six phylogeographical lineages, each associated with specific, sympatric human populations. In an urban cosmopolitan environment, mycobacterial lineages were much more likely to spread in sympatric than in allopatric patient populations. Tuberculosis cases that did occur in allopatric hosts disproportionately involved high-risk individuals with impaired host resistance. These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development. © 2006 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_5.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1413851/bin/pnas_0511240103_6.pdf
Authors & Co-Authors
Gagneux, Sébastien P.
Unknown Affiliation
DeRiemer, Kathryn
Unknown Affiliation
Van, Tran T.
Unknown Affiliation
Kato-Maeda, Midori
Unknown Affiliation
De-Jong, Bouke Catherine
Unknown Affiliation
Narayanan, Sujatha
Unknown Affiliation
Nicol, Mark P.
Unknown Affiliation
Niemann, Stefan
Unknown Affiliation
Kremeri, Kristin
Unknown Affiliation
Gutierrez, M. Cristina
Unknown Affiliation
Hilty, Markus
Unknown Affiliation
Hopewell, Philip C.
Unknown Affiliation
Small, Peter M.
Unknown Affiliation
Statistics
Citations: 996
Authors: 13
Affiliations: 13
Identifiers
Doi:
10.1073/pnas.0511240103
ISSN:
00278424
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study