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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
EPSTEIN-BARR VIRUS ANTIBODY LEVELS IN CHILDREN FROM THE WEST NILE DISTRICT OF UGANDA. Report of a Field Study
The Lancet, Volume 299, No. 7753, Year 1972
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Description
A pilot study to test the feasibility of a long-term cohort investigation into the relationship of Epstein-Barr (E.B.) virus to Burkitt's lymphoma was undertaken in the West Nile District of Uganda, where Burkitt's lymphoma is endemic. Antibodies to E.B. virus were assessed by the indirect immunofluorescence method using serum collected during the pilot survey in November, 1968, from 1122 children. At a second survey eighteen months later, all children were accounted for, and in 447 who were re-bled, antibody levels to E.B. virus had remained sufficiently stable to make a long-term study possible. The study also disclosed important epidemiological information about E.B. virus in the West Nile District. Thus by the age of three, 90% of children had detectable antibody to E.B. virus, but this percentage declined with age to about 75% by age fifteen. Results of the second survey indicate that the decline with age is best explained by a recent epidemic of E.B. virus with a differentially greater incidence in infants and young children. Although there was geographical variation in the proportion of children with E.B. virus antibodies consistent with a recent epidemic of E.B. virus, the pattern of variation bore no apparent relationship to the time-space clustering of Burkitt's lymphoma previously reported in the West Nile. © 1972.
Authors & Co-Authors
Kafuko, George W.
Uganda
East African Virus Research Institute
Kirya, Barnabas G.
Uganda
East African Virus Research Institute
Henderson, Brian E.
Uganda
East African Virus Research Institute
Munube, Germano M.R.
Uganda
East African Virus Research Institute
Tukei, Peter M.
Uganda
East African Virus Research Institute
Day, Nicholas Edward
France, Lyon
Centre International de Recherche Sur le Cancer
Henle, Gertrude E.
United States, Philadelphia
The Children's Hospital of Philadelphia
Henle, Werner
United States, Philadelphia
The Children's Hospital of Philadelphia
Morrow, Richard H.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Pike, Malcolm C.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Smith, Peter George
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Williams, Edward H.
Uganda, Nile
Kuluva Hospital
Statistics
Citations: 12
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1016/S0140-6736(72)90228-0
ISSN:
01406736
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Uganda