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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Determinants of aflatoxin levels in Ghanaians: Sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices
International Journal of Hygiene and Environmental Health, Volume 209, No. 4, Year 2006
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Description
Aflatoxins are among the most potent of carcinogens found in staple foods such as groundnuts, maize and other oil seeds. This study was conducted to measure the levels of aflatoxin B
1
(AFB
1
) albumin adducts in blood and aflatoxin M
1
(AFM
1
) metabolite in urine of people in a heavy peanut and maize consuming region of Ghana and to examine the association between aflatoxin levels and several socio-demographic factors and food handling and consumption practices. A cross-sectional study was conducted in four villages in the Ejura Sekyedumase district of Ghana. A socio-demographic survey was administered to 162 participants. Blood samples were collected from 140 and urine samples from 91 of the participants and AFB
1
albumin-adduct levels in blood and AFM
1
levels in urine were measured. High AFB
1
albumin-adduct levels were found in the plasma (mean±SD=0.89±0.46 pmol/mg albumin; range=0.12-3.00 pmol/mg; median=0.80 pmol/mg) and high AFM
1
levels in the urine (mean±SD=1,800.14±2602.01 pg/mg creatinine; range=non-detectable to 11,562.36 pg/mg; median=472.67 pg/mg) of most of the participants. There was a statistically significant correlation (r = 0.35; p = 0.007) between AFB
1
-albumin adduct levels in plasma and AFM
1
levels in urine. Several socio-demographic factors, namely, educational level, ethnic group, the village in which participants lived, number of individuals in the household, and number of children in the household attending secondary school, were found to be significantly associated with AFB
1
albumin-adduct levels by bivariate analysis. By multivariate analyses, ethnic group (p = 0.04), the village in which participants live (p = 0.02), and the number of individuals in the household (p = 0.01), were significant predictors of high AFB
1
albumin-adducts. These findings indicate strongly that there is need for specifically targeted post-harvest and food handling and preparation interventions designed to reduce aflatoxin exposure among the different ethnic groups in this region of Ghana. © 2006 Elsevier GmbH. All rights reserved.
Authors & Co-Authors
Jolly, Pauline E.
Unknown Affiliation
Jiang, Yi
Unknown Affiliation
Ellis, William Otoo
Unknown Affiliation
Awuah, Richard Tuyee
Unknown Affiliation
Nnedu, Obinna N.
Unknown Affiliation
Phillips, Timothy Dukes
Unknown Affiliation
Wang, Jiasheng
Unknown Affiliation
Afriyie-Gyawu, Evans
Unknown Affiliation
Tang, Lili
Unknown Affiliation
Person, Sharina D.
Unknown Affiliation
Williams, Jonathan H.
Unknown Affiliation
Jolly, Curtis M.
Unknown Affiliation
Statistics
Citations: 152
Authors: 12
Affiliations: 9
Identifiers
Doi:
10.1016/j.ijheh.2006.02.002
ISSN:
14384639
e-ISSN:
1618131X
Research Areas
Food Security
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Ghana