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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Differential loss of invariant natural killer T cells and FoxP3
+
regulatory T cells in HIV-1 subtype A and subtype D infections
Journal of Acquired Immune Deficiency Syndromes, Volume 63, No. 3, Year 2013
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Description
HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3+ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response. Copyright © 2013 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Flach, Britta S.
Uganda, Kampala
Makerere University
Naluyima, Prossy
Uganda, Kampala
Makerere University
Blom, Kim
Sweden, Stockholm
Karolinska Universitetssjukhuset
Gonzalez, Veronica D.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Eller, Leigh Anne
Uganda, Kampala
Makerere University
United States, Silver Spring
Us Military Hiv Research Program
Laeyendecker, Oliver B.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Baltimore
Johns Hopkins School of Medicine
Quinn, Thomas Charles
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Baltimore
Johns Hopkins School of Medicine
Serwadda, David Musoke
Uganda, Kampala
Makerere University College of Health Sciences
Uganda, Entebbe
Uganda Virus Research Institute
Sewankambo, Nelson K.
Uganda, Entebbe
Uganda Virus Research Institute
Uganda, Kampala
Makerere University College of Health Sciences
Wawer, Maria J.
Uganda, Entebbe
Uganda Virus Research Institute
United States, New York
Mailman School of Public Health
Gray, Ronald H.
Uganda, Entebbe
Uganda Virus Research Institute
United States, Baltimore
Johns Hopkins University
Michael, Nelson L.
United States, Silver Spring
Us Military Hiv Research Program
Wabwire-Mangen, Fred
Uganda, Kampala
Makerere University
United States, Silver Spring
Us Military Hiv Research Program
Robb, Merlin Lee
United States, Silver Spring
Us Military Hiv Research Program
Eller, Michael A.
Uganda, Kampala
Makerere University
United States, Silver Spring
Us Military Hiv Research Program
Sandberg, Johan K.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Statistics
Citations: 16
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1097/QAI.0b013e31828b2073
ISSN:
15254135
Research Areas
Infectious Diseases