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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antiviral efficacy and resistance in patients on antiretroviral therapy in Kigali, Rwanda: The real-life situation in 2002
HIV Medicine, Volume 7, No. 1, Year 2006
Notification
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Description
Our study aimed to complete the published data on ARV therapy in Africa by describing the baseline situation in Rwanda before the launch of a large ARV programme (ESTHER). Prescription habits, frequency and reasons for treatment interruptions but also antiviral efficay, resistance to ARVs and genotypic variability of the viruses present in Rwanda were analysed. Among the 233 patients included in the study, it appeared that a vast majority (91%) were under triple therapy and that half of them had experienced at least one treatment interruption caused mainly by drug shortage or financial difficulties. Among 60 blood samples analysed, 26 were in virological failure with a viral load above 1000 RNA copies/ml and 11 presented major drug resistance mutations. Finally, virological failure could mainly be explained by the high frequency of treatment interruptions but also by the emergence of drug resistance mutations. Consequently the major objective for the ESTHER programme to improve the situation in Rwanda will be to reduce the drug shortage and facilitate the financial accessibility of the treatments. © 2006 British HIV Association.
Authors & Co-Authors
Fischer, Aurélie
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Karasi, Jean Claude
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Kibibi, D.
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Omes, Christine
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Lambert, Christine
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Uwayitu, A.
Rwanda, Kigali
Centre Hospitalier Universitaire de Kigali
Hemmer, Robert J.P.
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
van den Ende, Jef J.
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Schmit, Jean Claude
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Arendt, Vic
Luxembourg, Luxembourg
Centre Hospitalier de Luxembourg
Statistics
Citations: 22
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1111/j.1468-1293.2005.00338.x
ISSN:
14642662
e-ISSN:
14681293
Research Areas
Infectious Diseases
Study Locations
Rwanda