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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic population structure of Anopheles gambiae in Equatorial Guinea
Malaria Journal, Volume 6, Article 137, Year 2007
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Description
Background. Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods. Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results. High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion. The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. © 2007 Moreno et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Moreno, Marta
Spain, Madrid
Centro Nacional de Medicina Tropical
Salgueiro, Patrícia
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Vicente, José Luís
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Cano, Jorge
Spain, Madrid
Centro Nacional de Medicina Tropical
Equatorial Guinea, Bata
Instituto de Salud Carlos Iii Bata
Berzosa, Pedro J.
Spain, Madrid
Centro Nacional de Medicina Tropical
de Lucio, Aída
Spain, Madrid
Centro Nacional de Medicina Tropical
Simard, Frédéric R.
France, Montpellier
Ird Centre de Montpellier
Cameroon, Yaounde
Organisation de Coordination Pour la Lutte Contre Les Endémies en Afrique Centrale
Caccone, Adalgisa
United States, New Haven
Yale University
do Rosário, Virgílio Estólio
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Pinto, João
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Benito, Agustìn
Spain, Madrid
Centro Nacional de Medicina Tropical
Statistics
Citations: 40
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1186/1475-2875-6-137
e-ISSN:
14752875
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Equatorial Guinea
Gabon
Guinea